Term
|
Definition
| Efflux, Change in PBP, B-Lactamase, alter porins |
|
|
Term
| Amoxicillin/clavulanic acid (Augmentin) |
|
Definition
Clavulanic acid inh. B-lactamase.
Use: Strep. Pneumo (+), H. Flu (-)
Adverse: Colitis, superinfection. Rash IS NOT allergic.
Pharm: Oral only. Renal excr. |
|
|
Term
|
Definition
Strep Pneumo, H. Flu (-), E. coli (-), Salmonella (-), Listeria (+), Proteus (-), Enterococci (+)
Pharm: Oral, IV. Renal excr. |
|
|
Term
|
Definition
Strep Pneumo (+), Neisseria meningitides (-), Syphillis
The class of drug don't work w/ chloramphenicol, macrolides, or tetracyclines (statics) |
|
|
Term
|
Definition
MSSA (+)
Pharm: IV. HEPATIC elimination |
|
|
Term
|
Definition
Pseudomonas (-)
Inhibits platelet coag
Pharm: IV. Renal excr. |
|
|
Term
|
Definition
Broader spectrum due to R group. Carbapenem.
Aerobic or anaerobic G+ or G- rods. reserve tx
Dizziness, headache
Cilastatin prevents renal degradation |
|
|
Term
|
Definition
1st gen Cephalosporin. 2 R groups.
Generally resistant to B-lactamase, broader spectrum
Staph and strep (+)
E. coli, proteus (-) |
|
|
Term
|
Definition
3rd gen cephalosporin. 2 R groups
Generally resistant to B-lactamase, broader spectrum
Enterobacter, serratia, gonorrhea (-)
Pseudomonas, meningitis
NOT USEFUL: MRSA, enterococcus, listeria, legionella, clostridium, campy, acinetobacter
Toxicity: Renal tubular epithelium |
|
|
Term
|
Definition
3rd gen cephalosporin. 2 R groups
Generally resistant to B-lactamase, broader spectrum
Enterobacter, serratia, gonorrhea (-)
Pseudomonas, meningitis
NOT USEFUL: MRSA, enterococcus, listeria, legionella, clostridium, campy, acinetobacter
Toxicity: Renal tubular epithelium |
|
|
Term
|
Definition
3rd gen cephalosporin. 2 R groups
Generally resistant to B-lactamase, broader spectrum
Enterobacter, serratia, gonorrhea (-)
Pseudomonas, meningitis
NOT USEFUL: MRSA, enterococcus, listeria, legionella, clostridium, campy, acinetobacter
Toxicity: Renal tubular epithelium |
|
|
Term
|
Definition
Monobactam. ONLY G- aerobes
No PCN allergy! |
|
|
Term
| B-lactam drug Interactions |
|
Definition
EtOH, disulfiram effects (flushing, cramps, nausea, sweating)
Bacteriostatics
H2 blockers, antacids
Enhanced nephrotoxicity, B-lactam inactivation
Probenecid potentiates action
GABA antagonists-irritability, tremors, seizures |
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|
