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Axiolytic-Hypnotics
Recognition Quiz
16
Pharmacology
Graduate
11/05/2011

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Cards

Term
Meprobamate
Definition
Anxiolytic, Rarely Used anymore
Term
Thiopental
Definition
Ultra-Short-Acting Barb, used in Induction of Anesthesia
Term
Pentobarbital
Definition
Short-Acting Barb, Anxiolytic, Metabolism and Renal Excretion are Major Paths to terminate Drug Action
Term
Barbiturates
Definition
Depress Medullary Respiratory Center, Potentiated by Alcohol, Induces Enzymes altering self/non-self drug metabolism, Tolerance, Dependence (Severe Withdrawal)
Term
Diazepam (Valium)
Definition
Long T 1/2, Causes Skeletal Muscle Relaxation
Term
Chlordiazepoxide
Definition
Benzodiazepine with Intermediate Elimination (T 1/2)
Term
Lorazepam (Ativan)
Definition
Benzodiazepine with Intermediate Elimination (T 1/2) Does NOT require Phase 1 Metabolism therefore is safer in patients with hepatic failure
Term
Alprazolam (Xanax)
Definition
Benzo used to treat Panic Attacks
Term
Midazolam
Definition
Short Acting Benzo
Term
Benzodiazepines
Definition
Don't Cause Anesthesia, Less Severe Withdrawal, Can Cause both CNS Depression or paradoxical CNS Activation and nightmares, Tolerance and Dependance, Selflimited Action
Term
Barbiturates
Definition
@ high doses can directly activate Cl channels
Term
Flumazenil
Definition
Benzodiazepine Receptor Antagonist
Term
Desmethydiazepam and Nordazepam
Definition
Active Benzo Metabolites
Term
Buspirone
Definition
Slow Onset Anxiolytic with low addiction potential, Does not potentiate alcohol CNS Depression, Minimal Sedation, Stimulates 5-HT1a receptor (No action on GABA)
Term
Zolpidem
Definition
Hypnotic that Works @ Benzodiazepine Receptor, No rebound insomnia, No Withdrawal, Minimal Tolerance may occur
Term
Eszopiclone (Lunesta)
Definition
Mirrors Benzo Action by binding GABA Receptors at the same site BUT no tolerance for at least 6 months making this hypnotic useful for treating Chronic Insomnia
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