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Autonomics Pharma
Autonomics Pharma
51
Medical
Graduate
05/22/2011

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Cards

Term
 Bethanechol
Definition
Direct M Ag
Use: postop ileus & urinary retention
Term
Carbachol
Definition
Direct M Ag
Use: glauc, pupillary contraction, release of IOP
Term
Piocarpine
Definition
Direct M Ag
Use: stims sweat, tears, & saliva
Note: resistant to AChE
Term
Methacholine
Definition
Direct M Ag
Mech: stims M in airway when inhaled
Use: challenge test for asthma dx
Term
Neostigmine
Definition
Indirect M Ag (Anticholinesterase)
Use: postop ileus & urinary retention; MG; postop reversal of NMJ block
Note: no CNS penetration (neo=no")"
Term
Pyridostigmine
Definition
Indirect M Ag (Anticholinesterase)
Use: MG (long-acting)
Note: no CNS penetration
Term
Edrophonium
Definition
Indirect M Ag (Anticholinesterase)
Use: MG dx (extremely short acting)
Term
Physostigmine
Definition
Indirect M Ag (Anticholinesterase)
Use: glauc & atropine OD (phys is for eyes")
Note: crosses BBB"
Term
Echothiophate
Definition
 Indirect M Ag (Anticholinesterase)
Note: irreversibleUse: glauc
Term
Parathoin
Definition
Irreversible non-comp AChE inhib -
others: malathion, sarin, soman
Antidote: atropine + pralidoxime (2-PAM)
Term
Pralidoxime
Definition
AChE reactivator
Use: combo with atropine for O-P tox
Term
Atropine
Definition
M Antag
Use: mydriasis & cycloplegia
Tox: hot as a hare
Term
Homatropine
Definition
M Antag
Use: mydriasis & cycloplegia
Term
Tropicamide
Definition
M Antag
Use: mydriasis & cycloplegia
Term
Benztropine
Definition
M AntagUse: Parkinson's dz
Term
Scopolamine
Definition
M Antag
Use: Motion sickness
Term
Ipratropium
Definition
M Antag
Use: Asthma; COPD
Term
Oxybutynin
Definition
M Antag
Use: decr urinary urgency
Term
Glycopyrrolate
Definition
M Antag
Use: decr urinary urgency
Term
Methscopolamine
Definition
M Antag
Use: peptic ulcer tx
Term
Pirenzepine
Definition
M Antag
Use: peptic ulcer tx
Term
Propantheline
Definition
M Antag
Use: peptic ulcer tx
Term
Hexamethonium
Definition
N Antag - non-depol Ganglionic blocker
Use: prevent vagal reflex response to changes in BP
Tox: orthostatic hypoTN, blurred vision, constip, sex dysfxn
Term
Rocuronium
Definition
N Antag - non-depol Ganglionic blocker
Tox: orthostatic hypoTN, blurred vision, constip, sex dysfxn
Term
Epi
Definition
Direct sympathomimetic (α1, α2, β1, β2)
Use: anaphylaxis, open angle glauc, hypoTN
Note: low doses selective for β1
Term
NE
Definition
Direct sympathomimetic (α1, α2 > β1)
Use: hypoTN
Term
Isoproterenol
Definition
Direct sympathomimetic (β1, β2)
Use: AV block (rare)
Term
DA
Definition
Direct sympathomimetic (D1=D2 > β > α)
Use: shock (dil. renal bv), HF
Note: inotropic & chronotropic
Term
Dobutamine
Definition
Direct sympathomimetic (β1 > β2)
Use: shock, HF, cardiac stress test
Note: inotropic, not chronotropic
Term
Phenylephrine
Definition
Direct sympathomimetic (α1 > α2)
Use: pupil dilation, vasoconstr, nasal decongestion
Term
Albuterol
Definition
Direct sympathomimetic (β2 > β1) - Selective β2-Ag
Use: acute asthma
Term
Terbutaline
Definition
Direct sympathomimetic (β2 > β1) - Selective β2-Ag
Use: reduces premature uterine contractions
Term
Ritodrine
Definition
Direct sympathomimetic (β2)
Use: reduces premature uterine contractions
Term
Amphetamine
Definition
Indirect sympathomimetic
Mech: releases stored catecholamines
Use: narcolepsy, ADD
Term
Ephedrine
Definition
Indirect sympathomimetic
Mech: releases stored catecholamines
Use: nasal decongestion, urinary incontinence, hypoTN
Term
Cocaine
Definition
Indirect sympathomimetic
Mech: catecholamines uptake inhibitor
Use: vasoconstr, local anesth
Term
Clonidine
Definition
α2 Ag (symp antag)
Use: HTN (esp w/ renal dz - no decr. flow to kidney)
Term
α-methyldopa
Definition
α2 Ag (symp antag)
Use: HTN (esp w/ renal dz - no decr. flow to kidney)
Term
Metaproterenol
Definition
Selective β2-Ag
Term
Salmeterol
Definition
Selective β2-Ag
Term
Phenoxybenzamine
Definition
Nonselective α-blocker (irrev)
Use: pheo
Tox: ortho hypoTN, reflex tachy
Term
Phentolamine
Definition
Nonselective α-blocker (rev)
Use: pheo
Tox: ortho hypoTN, reflex tachy
Term
Prazosin
Definition
α1-blocker - others: terazosin, doxazosin
Use: HTN, urinary retention in BPH
Tox: 1st-dose ortho hypoTN
Term
Mirtazapine
Definition
α2-blocker
Use: depression
Tox: sedation, incr. Chl, incr. appetite
Term
Propranolol
Definition
Nonselective β-blocker - others: timolol, nadolol, pindolol (partial - contra: angina)
Use: HTN, angina, MI (decr. mort), CHF, glauc (timolol - decr. aq. humor secr)
SE: impotence, exacerbation of asthma, CV effects, CNS effects (sedation)
Note: caution in DM
Term
Betaxolol
Definition
Selective β1-blocker - others: acebutolol (partial - contra: angina), esmolol (short-acting), atenolol, metoproplol
Use: HTN, angina, MI (decr. mort), CHF, glauc (timolol - decr. aq. humor secr)
SE: impotence, exacerbation of asthma, CV effects, CNS effects (sedation)
Note: caution in DM
Term
Labetolol
Definition
Nonselective α & β antag
Term
Carvedilol
Definition
Nonselective α & β antag
Term
Vesamicol
Definition
Anti-ACh
Mech: prevents ACh loading into vesicles
Term
Reserpine
Definition
Anti-adrenergic
Mech: prevents loading of DA into vesicles
Term
Guanethidine
Definition
Anti-adrenergic
Mech: prevents vesicle release
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