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Autonomic Nervouss system
pharm...
29
Dentistry
Undergraduate 3
10/01/2014

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Cards

Term
are postganglionic neurons close to effector program?
Definition
postganglionic neurons are not close to effector program.
Term
is the neuromuscular junction a part of ANS?
Definition
no neuromuscular junction is not part of ANS but it does use acetylcholine and is termed cholinergic.
Term

Sans + adrenergic drug

sympathomimetrics

Definition
epinephrine
Term

SANS - adrenergic blocker drug (alpha or beta)

sympatholytic drugs

Definition

beta blockers because they can block receptor cites from making epi.

 

-examples: propranolol(inderal)

depresses heart and bronchoconstriction

used for arrythmias, angina, hypertension, also neuromuscular blocking drugs.

Term

Pans + cholinergic drugs/parasympatemimetrics

(make wet)

Definition
salagen, pilocarpene, laxatives
Term

Pans -  ( AKA: anticholinergic drugs)

parasympatholytics / block cholinergic drugs.

Definition

stops wetness

cholinesterase (for myasthenia gravis)

amphetamines

Term
drugs that act at location of pans have what prefix
Definition
parasympatho
Term
drugs that act at sans location have prefix
Definition
sympatho
Term
drugs that act at location where division of ANS acts and produces effect on ANS as a neurotransmitter has suffix______. and is an agonist
Definition
mimetric is an agonist.
Term
drugs that block action of neurotransmitter has what suffix, this is an antagonist.
Definition
lytic is a blocker or antagonist.
Term
uses for cholinergic drugs
Definition

decrease cardiac output, 

vasodilation

helps GI move things along

helps with glaucoma

helps for genitourinary retention.

Term
when we make things too wet, there are adverse reactions of cholinergic drugs what are they?
Definition

salivation

lacrimation

urination

defectation

 

 

slud

Term
what are contraindications of cholinergics?
Definition

increases asthma attacks

 

increase in atrial fibrilation in hyperthyroidism

 

GI obstruction or back up caused

 

severe cardiac disease

 

neostigmine for myasthenia gravis pts

 

peptic ulcer

Term
what is a drug that is often  prescribed for myasthenia gravis that does not work because it is anticholinergic.
Definition
neostigmine
Term
what are some effects of anticholinergics
Definition

cns stimulation or depression (depends on dose)

 

exocrine glands decrease flow and volume of secretions (respiratory, GI, GU)

 

decrease in salivation

 

relaxes smooth muscle in respiratory and GI treat asthma and diarrea

 

dilates pupils and paralyse eyes

 

blocks vagus nerve

 

increase HR

Term
what are some adverse reactions with anticholinergics?
Definition

xerostomia

blurred vision

tachycardia

fever

urinary and GI stasis

 

cns excitations and hallucenations (amphetamines)

Term
mydriasis
Definition
dilates pupils anticholinergics
Term
cylopegia
Definition
paralysis of pupils (anticholinergics P-)
Term
contraindications of anticholinergics
Definition

glaucoma

 

prostatic hypertrophy

 

GI obstruction

 

cardiac pts

Term
why would you use anticholinergics on parkinsons pt?
Definition

used before levodopal

 

reduces tremors and rigidity

 

 

Term
what is good to make a dry field in dentistry and also is good for motion sickness?
Definition
anticholinergic drugs good for dentistry and motion sickness
Term
what drugs should not be combined with anticholinergic drugs?
Definition
antihistimines, phenothiazines, and tricyclic antidepressents
Term
atropine sulfate
Definition
anticholinergic drug used in dentistry (pre-op) and for diarrhea
Term
SANS adrenergic receptors can be
Definition

alpha

 

beta 1 

 

beta 2

Term
alpha receptor sites for SANS
Definition
stimulation results in smooth muscle excitation or contraction.
Term
Beta 1 receptors sites SANS
Definition

stimulate smooth muscle excitation

-increase heart rate strength

 

-glycogen formation

Term
Beta 2 receptor cite SANS
Definition

stimulates smooth muscle relaxation/inhibition

-vasodilation of blood vessels

-relaxation of bronchioles

-treat asthma

Term
what are adverse reactions of SANS
Definition

anxiety

tremors

palpitation

serious arrythmias

Term
what may SANS drugs be used for
Definition

glaucoma

 

CNS, attention defecit disorder, narcolepsy

 

shock: dopamine

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