Term
|
Definition
| direct cholinergic agonist (M=N) |
|
|
Term
|
Definition
| direct cholinergic agonist (M>N) |
|
|
Term
|
Definition
direct cholinergic agonist (M=N)
not hydrolyzed by cholinesterase
quaternary ammonium |
|
|
Term
|
Definition
direct cholinergic agonist (M>N)
not hydrolyzed by cholinesterase
quaternary ammonium |
|
|
Term
|
Definition
direct cholinergic partial-agonist (M>N)
not hydrolyzed by cholinesterase
used to lower ocular pressure in glaucoma
enters brain (tertiary amine) |
|
|
Term
|
Definition
found on postjunctional, postsynaptic, and erythrocyte membranes
hydrolyzes ACh>methacholine>butyrylcholine>succinylcholine(0) |
|
|
Term
|
Definition
found on non-neuronal (e.g. glial) cells, plasma (synthesized in liver)
hydrolyzes butyrylcholine>ACh>succinylcholine>methacholine(0) |
|
|
Term
|
Definition
| carbamate reversible cholinesterase inhibitor |
|
|
Term
|
Definition
carbamate reversible cholinesterase inhibitor
quaternary ammonium |
|
|
Term
|
Definition
| carbamate reversible cholinesterase inhibitor |
|
|
Term
|
Definition
carbamate reversible cholinesterase inhibitor
used for Alzheimer's disease |
|
|
Term
|
Definition
reversible cholinesterase inhibitor
low affinity, small Vd, rapid clearance (renal)
diagnostic in myasthenia gravis
quaternary ammonium |
|
|
Term
|
Definition
reversible cholinesterase inhibitor
selectively penetrates brain
longer duration (single daily dose)
formerly used for Alzheimer's disease - no effect
liver toxicity in 30% |
|
|
Term
|
Definition
reversible cholinesterase inhibitor
selectively penetrates brain
longer duration (single daily dose)
used for Alzheimer's disease |
|
|
Term
|
Definition
| irreversible cholinesterase inhibitor |
|
|
Term
|
Definition
irreversible cholinesterase inhibitor
used for glaucoma
quaternary ammonium |
|
|
Term
|
Definition
muscarinic agonist
tertiary amine, enters CNS |
|
|
Term
|
Definition
nicotinic agonist
both sympatho- and parasympathomimetic
CV: SNS; GI/U: PNS
NMJ: depolarization, contraction |
|
|
Term
|
Definition
nicotinic agonist
both sympatho- and parasympathomimetic
CV: SNS; GI/U: PNS
NMJ: depolarization, contraction |
|
|
