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Autonomic Drugs
mechanism of action, side effect
51
Pharmacology
Professional
01/30/2010

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Cards

Term
pilocarpine
Definition
direct muscarinic agonist
mechanism- stimulate ACh receptor
S.E.- DUMBBELS
Term
bethanechol
Definition
direct muscarinic agonist
mechanism- stimulate ACh receptor
S.E.- DUMBBELS
Term
nicotine
Definition
direct nicotinic agonist
mechanism- stimulate ACh receptor
S.E.- DUMBBELS
Term
succinylcholine
Definition
direct nicotinic agonist
mechanism- stimulate ACh receptor
S.E.- DUMBBELS
Term
varenicline
Definition
Partial nicotinic agonist
mechanism- stimulate ACh receptor
S.E. DUMBBELS
Term
Acetylcholine
Definition
direct agonist of both M and N
mechanism- stimulate ACh receptor
S.E. DUMBBELS
Term
physostigmine
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
long duration
Term
neostigmine
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
long duration
Term
demecarium
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
long duration
Term
edrophonium
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
reversible inhibitors, short duration
Term
echothiophate
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
phosphorylates enzyme
Term
donepezil
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
for Alzheimer's
Term
tacrine
Definition
Indirect cholinergic agonist
mechanism- prevent breakdown of ACh
S.E.- DUMBBELS
for Alzheimer's
Term
prelidoxime
Definition

Indirect cholinergic agonist mechanism- prevent breakdown of ACh S.E.- DUMBBELS

-reverses phosphoylation of AChE

Term
malathion
Definition
Ach inhibitor used as insecticide
Term
sarin
Definition
ACh inhibitor used in chemical warfare
Term
atropine
Definition
Antimuscarinic
mechanism- block muscarinic receptor
S.E.- opposite of DUMBBELS
Term
scopolamine
Definition
Antimuscarinic
mechanism- block muscarinic receptor
S.E.- opposite of DUMBBELS
Term
trimethaphan
Definition
antinicotinic
mechanism of action- ganglionic blocker
used in hypertensive emergency
Term
mecomylamine
Definition
antinicotinic
mechanism of action- ganglionic blocker
used in hypertensive emergency
Term
depolarizing succinylcholine
Definition
antinicotinic
mechanism- ACh analog that initally acts like ACh and causes depolarization but ultimately causes hyperpolarization and therefore paralysis
S.E.- paralysis
Term
tubocurarine
Definition
antinicotinic- non-depolarizing
mechanism- block the skeletal muscle nicotinic receptor
Term
pancuronium
Definition
antinicotinic- non-depolarizing
mechanism- block the skeletal muscle nicotinic receptor
Term
atracurium
Definition
antinicotinic- non-depolarizing
mechanism- block the skeletal muscle nicotinic receptor
Term
doxacurium
Definition
antinicotinic- non-depolarizing
mechanism- block the skeletal muscle nicotinic receptor
Term
suggamadex
Definition
antinicotinic
mechanism- reverses non-depolarizing antinicotinics by binding to the drug- e.g. tubocurarine
Term
botulinum toxin type A
Definition
antinicotinic
mechanism- inhibits ACh release from preganglionic neuron
Term
epinephrine
Definition
adrenergic agonist on alpha and beta
mechanism- binds a and b receptors
causes inc. BP, inc HR
Term
phenylephrine
Definition
mechanism- adrenergic agonist on a1 receptor
vasoconstrictor
Term
clonidine
Definition
mechanism- adrenergic agonist on a2 receptor
dec. BP
Term
Alpha methyl norepinephrine
Definition
mechanism- adrenergic agonist on a2 receptor
dec. BP
Term
norepinephrine
Definition
mechanism- adrenergic agonist on B1
Term
dobutamine
Definition
mechanism- adrenergic agonist on B1
Term
metaproterenol
Definition
mechanism- adrenergic agonist on B2
bronchodilation
Term
terbutaline
Definition
mechanism- adrenergic agonist on B2
bronchodilation
Term
fenoterol
Definition
mechanism- adrenergic agonist on B2
bronchodilation
Term
albuterol
Definition
mechanism- adrenergic agonist on B2
bronchodilation
Term
amphetamine
Definition
indirect acting amine
mehcanism- induces relase of NE from terminals
CNS stimulant
Term
tyramine
Definition
indirect acting amine
mehcanism- induces relase of NE from terminals
CNS stimulant
Term
phenylpropanolamine
Definition
indirect acting amine
mehcanism- induces relase of NE from terminals
CNS stimulant
Term
pseudoephedrine
Definition
indirect acting amine
mehcanism- induces relase of NE from terminals
CNS stimulant
Term
hydroxyamphetamine
Definition
indirect acting amine
mehcanism- induces relase of NE from terminals
CNS stimulant
Term
prazosin
Definition
mechanism- antagonist of A1
dec. BP
Term
phenoxybenzamine
Definition
mechanism- antagonist of A1
dec. BP
Term
phentolamine
Definition
antagonist on A1 and A2
Term
tolazine
Definition
antagonist on A2
Term
metroprolol
Definition
antagonist on B1
dec. HR- for hypertension
Term
acebutolol
Definition
antagonist on B1
dec. HR- for hypertension
Term
aldrenolol
Definition
antagonist on B1
dec. HR- for hypertension
Term
esmolol
Definition
antagonist on B1
dec. HR- for hypertension
Term
propanolol
Definition
mechanism- antagonist on B1 and B2
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