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autonomic drugs
usmle review
43
Medical
Graduate
06/01/2009

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Cards

Term
bethanocol mech, use, tx
Definition
m2/3 agonist, leaves 1 alone. post op illeus/ urinary retention. causes contraction of bladder/ peristalsis. tx: slow heart, sweating, poopy
Term
carbachol, use, general class
Definition
eye drops. ach agonist, causes miosis and release of intraocular pressure e.g. open angle glaucoma and following eye surgery
Term
pilocarpine
Definition
glaucoma treatment eye drops. oncracts cilliary muscle of eye (open angle) and pupillary sphincter (narrow angle). big time sweat/ tears stimulator. resistant to ache
Term
methacholine
Definition
stimulates msucarinic receptoors in airway when inhaled m3 agonist
Term
neostigmine
Definition
post operative and neurogenic ileus and primary urinary retention, myasthetnia gravis, reversal of neuormuscular juntion blockade (phase II). raises endogenous ach no cns penetration neo cns= NO CNS
Term
physostigmine
Definition
ache blocker that can cross cns border and can thusly be used to reverse atropine overdose, also used in eye to produced miosis and releif of glaucoa.
Term
pyridostigmine
Definition
long acting (pyramids were long lasting) does not penetrate cns.
Term
edrophonium
Definition
short acting ache for dx of myasthenia gravis
Term
echtiophate
Definition
glaucoma
Term
atropine
Definition
m1,2,3 antagonist. red as a beet, hot as a hare, dry as a bone, blind as a bat, mad as a hatter. can cause angle closure glaucoma and urinary retention with glaucoma
Term
scopolamine
Definition
motion sickness muscarinic antagonist
Term
benzotropine
Definition
m1, m2 m3 antagonist good for reudcing gaba over activity in parkinsons, contraindicated in narrow angle glaucoma just like atropine
Term
ipratroium
Definition
inhaled m3 antagonist, leading to bronchodilation for asthma/copd "I pra" i can breathe soon
Term
propantheline
Definition
peptic ulcer treatment (less gastric secretion from blocking m3 receptors)
Term
methscpolamine
Definition
peptic ulcer treatment (less gastric secretion from blocking m3 receptors)
Term
pirenzepine
Definition
peptic ulcer treatment (less gastric secretion from blocking m3 receptors)
Term
oxybutynin
Definition
reduces urgency in mild cystintis and bladder spasmsmuscarinic antagonist
Term
hexamethonium
Definition
nictonic antagonist, ganglionic blocker, used in experiments to prevent vagal reflex respoinses. causes orthostatic hypotension, blurred vision, constipation and sexual dysfunction
Term
ne
Definition
alpha 1 and alpha2 b1 at high doses, good pressor, decreases renal blood flow, decreases hr despit b1 activity (reflex)
Term
isoproternol
Definition
b1 and b2 agonist, decreases systolic a bit (less return) and very much decreases diastolic (b2), increases hr(b1) for AV heart block
Term
dopamine
Definition
d1=d1>b1>a1
Term
dobutaline
Definition
b1>b2
Term
phenylephrine
Definition
a1>a2. pupillary dilation vaso constriction, nasal decongestion
Term
albuterol, terbutaline
Definition
b2>b1 terubutaline decreses premature uterine contractions
Term
ritrodrine
Definition
b2 reduces preamture uterine contractions
Term
ephedrine
Definition
nasal decongestion urinary inconteinence hypotension
Term
mechanism of amphetamine
Definition
release of stored catecholes
Term
cocaine
Definition
general reuptake inhibitor serotonin, dopamine, ne
Term
clonidine
Definition
alpha2 agonist reduced output of sympathetics. hypertension treatment, specially in pregos. also used in hypertension with reneal disease.
Term
metaproterenol
Definition
b2 agonist
Term
phenoxybenzamine
Definition
pheochromocytoma treatment, can cause othostatic hypotenstion and reflex tachycardia
Term
prazosin terazosin, doxazosoin
Definition
alpha 1 blockers. hypertension and urinary retention in BPH. orthostatic hypotension, dizziness, heachacne
Term
phentolamine vs phenoxybenzamine
Definition
phentolamine is reversible vs irreversible phenoxybenzamine
Term
mirtazapine
Definition
alpha 2 selective blocker used for depression, causes sedation higher serumc choleserol and more appetite.
Term
acebutolol
Definition
b1 selective partial agonist
Term
betexolol
Definition
b1 selective
Term
atenolol
Definition
b1 seletive blocker
Term
metoprolol
Definition
b1 selective antagonist
Term
propanolol
Definition
non selective b blocker
Term
timolol
Definition
non selective b blocker
Term
nadolol
Definition
non selective b blocker
Term
pindolol
Definition
non selective b blocker partial agonist
Term
labetalol
Definition
non selective b blocker
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