Term
| AI disorders result when the body fails to recognise self from nonself. List causes of the loss of self tolerance. (4) |
|
Definition
| genetic and environmental factors-bacterial or viral infections trigger inflammation |
|
|
Term
| why are women more prone to AI diseases |
|
Definition
| estrogen is the leading hormone associated with AI diseases |
|
|
Term
| typical profile of an individual suffering from SLE |
|
Definition
| woman, 20-40 yrs, ethnic minority |
|
|
Term
| give clinial signs of SLE (3) |
|
Definition
| butterfly rash, arthritis, anorexia |
|
|
Term
| Give 4 factors (environmental and genetic) that can cause SLE |
|
Definition
| loss of tcell suppression, hormone influences, environment, drug induced |
|
|
Term
| neutrophil that engulfs an ab-covered neutrophil is called |
|
Definition
|
|
Term
| list 5 clinical immunologic findings in SLE |
|
Definition
LE cell, dsDNA, anti-sm (SLE specific)
antissDNA, histone (not SLE specific) |
|
|
Term
| what is the screening test for lupus? what is its drawback? |
|
Definition
fana testing
produces many false pos |
|
|
Term
| list 4 AI disorders & collagen diseases that result in antinuclear ab's |
|
Definition
| SLE, RA, scleroderma, sjogrens syndrome |
|
|
Term
| homogenous ana pattern is associated with what ab &disease |
|
Definition
| anti histone; drug induced lupus |
|
|
Term
| peripheral ana pattern is associated with what ab &disease |
|
Definition
|
|
Term
| speckled ana pattern is associated with what ab &disease |
|
Definition
| anti smith; diagnostic for SLE |
|
|
Term
| nucleolar ana pattern is associated with what ab &disease |
|
Definition
|
|
Term
| how are + ana tests confirmed |
|
Definition
| immunodiffusion (ouchterlony method) to id specific AB |
|
|
Term
| the detection of antismith ab is diagnostic for sle but if it is not present sle cannot be ruled out...explain this |
|
Definition
| antism is lupus specific but only seen in 30% of lupus pts |
|
|
Term
| what population (sex & age) typically suffers from RA |
|
Definition
|
|
Term
| a pos RF test is not diagnostic for RA, nor does a neg rule it out...explain |
|
Definition
| rf is not ra specific; it is only seen in 80% of ra pts |
|
|
Term
| The RF is ___ antibodies against ___ antibodies. |
|
Definition
|
|
Term
| hashimotos is the result of an autoab to _____ |
|
Definition
|
|
Term
| graves disease is the result of an autoab to _____ |
|
Definition
| TSI (against TSH receptors) |
|
|
Term
| which disease results in HYPOthyroidism |
|
Definition
|
|
Term
| which disease results in HYPERthyroidism |
|
Definition
|
|
Term
| what is the expected TSH result in graves disease |
|
Definition
|
|
Term
| organ attacked in addisons disease |
|
Definition
|
|
Term
| organ attacked in AI hemolytic anemia |
|
Definition
|
|
Term
| organ attacked in pernicious anemia |
|
Definition
|
|
Term
| organ attacked in rheumatic fever |
|
Definition
|
|
Term
| organ attacked in scleroderma |
|
Definition
|
|
Term
| organ attacked in sjogrens syndrome |
|
Definition
|
|
Term
| organ attacked in both hashimotos and graves |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| organs attacked in SLE (6) |
|
Definition
| skin, joints, kidneys, heart, lungs, brain |
|
|
Term
| organ attacked in IDDM (inuslin dependant diabetes mellitus) |
|
Definition
|
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