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Autoimmune Dermatology Drugs
N/A
18
Science
Professional
10/14/2011

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Cards

Term
Which of the following drugs would not be a good choice for a cat?

a. chlorambucil
b. prednisolone
c. azathioprine
d. cyclosporine
e. leflunomide
Definition
c. azathioprine--can cause fatal neutropenia in cats
Term
Which drug(s) cause(s) signs of iatrogenic hyperadrenocorticism? What are the clinical signs of this disease?
Definition
Prednisone, Prednisolone

Clinical signs: PU/PD, polyphagia, weight gain, CNS signs, behavioral/secondary changes, pancreatitis, GI ulcers, steroid hepatopathy, panting, secondary infections
Term
What is the glucocorticoid of choice in cats?
Definition
Prednisolone
Term
What is the immunosuppressive dose of GC?
Definition
2.2 mg/kg PO q24h
Term
What is the mechanism of action for azathioprine?
Definition
Anti-metabolite

Cytotoxic
Term
Which drug has side effects that include: myelosuppression, gastroenteritis, pancreatitis, and neuromuscular blockade?
Definition
Azathioprine
Term
What is the mechanism of action for chlorambucil?
Definition
Alkylating agent

Cytotoxic
Term
Which of the following is more suitable for use in a cat?

a. Azathioprine
b. Chlorambucil
Definition
b. Chlorambucil
Term
What are some side effects of chlorambucil administration?
Definition
Myelosuppression
Anorexia
Term
Which of the following drugs works as a pyrimidine synthesis inhibitor, causing inhibition of cytokines involved in cellular differentiation and signal transduction?

a. Chlorambucil
b. Leflunomide
c. Prednisolone
d. Pentoxyfylline
Definition
b. Leflunomide
Term
Gold salts can be used in autoimmune skin diseases. What is their mechanism of action?
Definition
Inhibit chemotaxis
Inhibit phagocytosis
Inhibit complement activation
Inhibit antibody formation
Term
Which drug(s) can cause cutaneous drug eruptions, eosinophilia, or thrombocytopenia as a side effect of administration?
Definition
Gold salts--aurothiomalate, auranofin
Term
Which two drugs work by inhibiting cell-mediated immunity through inhibition of IL2 production and subsequent inhibition of sensitized CTLs, and decreased antibody formation to T-cell dependent antigens?
Definition
Cyclosporine
Tacrolimus
Term
______________ is 10 times more potent than cyclosporine, requiring owners to wear gloves before topical application to their pet.
Definition
Tacrolimus
Term
_________ works synergistically with niacinamide.
Definition
Tetracycline
Term
What is the mechanism of action of tetracycline + niacinamide?
Definition
Niacinamide: inhibits IgE dependent histamine release, prevents mast cell degranulation, decreases protease release from leukocytes

Tetracycline: inhibits chemotaxis of leukocytes
Term
Which of the following drugs works by inhibiting TNF-alpha, inhibiting lymphocyte activation, and decreasing neutrophil degranulation? It also improves RBC deformity.

a. pentoxyfylline
b. aurothiomalate
c. tacrolimus
d. leflunomide
Definition
a. pentoxyfylline
Term
Which drug has side effects that include: gastroenteritis, gingival hyperplasia, nephrotoxicosis, papillomatosis, and hepatotoxicosis?
Definition
Cyclosporine
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