Term
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Definition
| prevention of an immune response against self structures |
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Term
| what is central tolerance? |
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Definition
it's deletion of lymphocytes before they mature.
-takes place in generative lymphoid organs |
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Term
| What is Peripheral tolerance? |
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Definition
either renders self-reactive lymphocytes nonresponsive or actively generates inhibiting lymphocytes.
-occurs outside bone marrow and thymus. |
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Term
| what is antigen sequestration? |
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Definition
| one means to protect self-antigens from attack |
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Term
| what does central tolerance limit? |
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Definition
| it limits the development of auto-reactive T & B cells |
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Term
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Definition
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Term
| What does peripheral tolerance do to auto-reactive cells in the circulation? |
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Definition
| it regulates auto-reactive cells in the circulation |
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Term
| what does failure of tolerance lead to? |
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Definition
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Term
| what are the risk factors for autoimmune disease? |
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Definition
- genetic (HLA type)
- Female
- Environmental
- Drugs
- Infections
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Term
| List the genetic (HLA type): |
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Definition
- HLADR2 with systemic lupus erythematosis (SLE) and multiple sclerosis (MS)
- HLADR3 with Sjogren's syndrome, Myasthenia gravis (MG), SLE & DM-1
- HLADR4 with Rheumatoid Arthritis (RA) & Diabetes mellitus type I (DM-1)
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Term
| describe Hashimoto's thyroidits: |
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Definition
Autoantibodies & sensitized TH1 cells specific for thyroid Ag are produced.
- more common in women
- Ab produced interferes with iodine uptake
- decreases thyroid function leading hypothyroidism
- Induces DTH response in the thyroid
- inflammation results in a goiter-visible enlargement of the thyroid gland
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