Term
|
Definition
PGE1 anaolog used to dilate ductus arteriosis to increase pulmonary blood flow and oxygenation
also used locally to promote erection |
|
|
Term
|
Definition
| PGI2 anaolg used for relief of pulmonary hypertension, and severe PVD. improves harvest and storage of platelets. used as a substitute for heparin during dialysis |
|
|
Term
|
Definition
| PGI2 analog used for anticoagulation effects. |
|
|
Term
|
Definition
PGI2 analog used for anticoagulation effects.
also used for supression of gastric ulceration |
|
|
Term
|
Definition
| PGI2 analog used for anticoagulation effects. |
|
|
Term
|
Definition
| PGI2 analog used for anticoagulation effects. |
|
|
Term
| Actions of PGE2 in cardiovascular system |
|
Definition
| Lowers BP by direct dilation of coronary vessels, decreasing NE release, and attenuation of ADH, AGII, etc. Suppresses arrhythmias and decreases free oxygen radical generation. |
|
|
Term
| PGE2 actions in the Renal system |
|
Definition
veno-vasodilation by directly decreasing vascular resistance and increases renal blood flow. promotes natriuresis, kaluresis and decreases CL- reabsorption.
decreases action of vassopressin on collecting duct permeability to water.
increases renin secretion |
|
|
Term
| Actions of PGI2 in cardiovascular system |
|
Definition
Lowers BP by direct dilation of coronary vessels, decreasing NE release, and attenuation of ADH, AGII, etc. Suppresses arrhythmias and decreases free oxygen radical generation.
inhibits platelet aggregation in endothelial cells |
|
|
Term
| PGI2 actions in the Renal system |
|
Definition
veno-vasodilation by directly decreasing vascular resistance and increases renal blood flow. promotes natriuresis, kaluresis and decreases CL- reabsorption, but not as much as PGE2
increases renin secretion |
|
|
Term
| PGE2 actions in the respiratory system |
|
Definition
|
|
Term
| PGI2 actions in the respiratory system |
|
Definition
|
|
Term
| PGI2 actions in the gastrointestinal system |
|
Definition
| decreases gastric acid and pepsin secretion. |
|
|
Term
| PGE2 actions in the gastrointestinal system |
|
Definition
| decreases gastric acid and pepsin secretion. contracts longitudinal smooth muscle and may shorten GI transit time |
|
|
Term
| PGE2 actions in the reproductive system |
|
Definition
relaxes non-pregnant uterus but contracts pregnant uterus
induces abortion and decreases postpartum hemorrhage |
|
|
Term
| PGF2α actions in the reproductive system |
|
Definition
contracts pregnant and non-pregnant uterus
causes regression of corpus luteum
induces abortion and decreases postpartum hemorrhage |
|
|
Term
| PGF2α actions in the respiratory system |
|
Definition
|
|
Term
| PGF2α actions in the gastrointestinal system |
|
Definition
| contracts longitudinal smooth muscle and may shorten GI transit time |
|
|
Term
| TxA2 actions in cardiovascular system |
|
Definition
| increases BP, stimulates platelet aggregation, constricts coronary vessels |
|
|
Term
| TxA2 actions in respiratory system |
|
Definition
|
|
Term
|
Definition
| produces skin flushing and is released by nicotinic acid from epidermal Langerhans cells |
|
|
Term
| PGE2 actions in nervous system |
|
Definition
causes hyperthermia, induces fever in CNS
sensitizes nerve endings to pain from chemical and mechanical stimuli causing hyper algesia |
|
|
Term
|
Definition
| decrease NE release and decreases constriction of lood vessels by NE, AGII, and vasopressin |
|
|
Term
|
Definition
| decrease NE release and decreases constriction of lood vessels by NE, AGII, and vasopressin |
|
|
Term
| PGE2 effects on metabolism |
|
Definition
| decrease basal and catecholamine induced lipolysis in adipose tissue and heart |
|
|
Term
| PGI2 effects on metabolism |
|
Definition
| decrease basal and catecholamine induced lipolysis in adipose tissue and heart |
|
|
Term
|
Definition
| PGE1 analog for supression of gastric ulceration |
|
|
Term
|
Definition
| PGE1 analog for supression of gastric ulceration |
|
|
Term
|
Definition
| PGF2α analog used to induce labor and abortion |
|
|
Term
|
Definition
PGE2 analog used to induce labor and abortion
also used for dilation of cervix for uterine examination |
|
|
Term
|
Definition
| 15-methyl-PGF2α analog used to induce labor and abortion |
|
|
Term
| PGI2 actions in the peripheral nervous system |
|
Definition
| sensitizes nerve endings to pain from chemical and mechanical stimuli causing hyper algesia |
|
|
Term
|
Definition
| PGF2α analog used for reducing resistance caused by hydrostatic pressure of uveoscleral outflow in glaucoma patients |
|
|
Term
|
Definition
| PGF2α analog used for increasing eyelash length, thickness, and darkness in patients with hypotrichosis of the eyelashes |
|
|
Term
|
Definition
| Kallikrein inhibitor, natural protinease inhibitor, ihibits mediators of the inflammatory response, fibrinolysis, and thrombin generation during bypass surgery. used to reduce blood loss during bypass surgery |
|
|
Term
|
Definition
| recombinant form of human BNP causes natriuresis, diuresis, dilates vascular smooth muscle in veins and arteries, decrease central venous pressure, inhibits aldosterone synthesis. used to treat dyspnea in CHF |
|
|
Term
|
Definition
| Endothelin receptor antagonist. blocks ET1 A and B receptor. used for treatment of pulmonary hypertension. can cause hepatotoxicity and peripheral edema |
|
|
Term
|
Definition
| Endothelin receptor antagonist. blocks ET1 A receptor. used for treatment of pulmonary hypertension. can cause hepatotoxicity, flushing, and may interact with warfarin |
|
|
Term
|
Definition
| Endothelin receptor antagonist. blocks AT1 receptor. used for treatment of pulmonary hypertension. can cause flushing, hepatotoxicity (less than others) |
|
|
