Term
| What are the 2 drugs approved for pediatric use? |
|
Definition
| Risperidone and Aripiprazole |
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|
Term
| Which drugs tend to show EPS effects? |
|
Definition
| Risperidone (>6mg; >1mg in elderly), paliperidone (>12 mg), Lurasidone |
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|
Term
| What are the notable drug interactions with risperidone? |
|
Definition
| Paroxetine (increases levels) and Carbamazepine (decreases levels) |
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Term
| Which medication is only available in sublingual form? |
|
Definition
|
|
Term
| which medication may have a tablet shell remaining in feces? |
|
Definition
|
|
Term
| What drug is a good option for the hepatically impaired? |
|
Definition
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|
Term
| Which drug is the only one approved for schizoaffective disorder |
|
Definition
|
|
Term
| what is the drug combo used in tandem to treat both schizo & depression |
|
Definition
|
|
Term
| Which drugs must be taken with food? Which drug must avoid food after administration and for how long? |
|
Definition
| Ziprasidone & lurasidone (at least 350 cals); Asenapine for 10 minutes. |
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|
Term
| What are aripiprazole's side effects? What can one of them be treated with? |
|
Definition
| Akathisia and vomiting. Akathisia can be treated with propranolol, up to 160 mg/d |
|
|
Term
| What pregnancy category are the medications? |
|
Definition
| All are C, save Clozapine (category B) |
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|
Term
|
Definition
|
|
Term
| What drugs require no alteration to dosing in the case of both renal and hepatic impairment? |
|
Definition
| Aripiprazole & Ziprasidone |
|
|
Term
| Which drug is a partial dopamine agonist? |
|
Definition
|
|
Term
| I can cause anticholinergic effects, weight gain, hyperglycemia, lipid increase, and sedation. Which drug am I? |
|
Definition
|
|
Term
| Which drug can give you diabetes? |
|
Definition
|
|
Term
| Under what conditions should the dose of Iloperidone be decreased, and by how much? |
|
Definition
| by 50%: with 2D6 inhibitors (paroxetine, fluoxetine, qunidine); with 3A4 inhibitors (ketoconazole, clarithromycin); and with poor 2D6 metabolizers |
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|
Term
| Which drug must not exceed 40mg under particular conditions, and what are those conditions? |
|
Definition
| Lurasidone, if CrCl<40mg/d, moderate-severe hepatic impairment, moderate 3A4 inhibitors (CONTRAINDICATED: strong 3A4 inhibitor OR Inducer) |
|
|
Term
| What are the side effects shared by risperidone and paliperidone? |
|
Definition
| hyperprolactinemia and dose-related EPS |
|
|
Term
| Which drug has the lowest chance of weight gain among antipsychotics? |
|
Definition
|
|
Term
| Which drug undergoes extensive hepatic aldehyde oxidase metabolism? |
|
Definition
|
|
Term
| Which drug have less metabolic effects? |
|
Definition
|
|
Term
| What are quetiapine's SE's? |
|
Definition
| sedation, weight gain, cataracts (animal trials), and blood sugar issues (but not to the extent of olanzapine |
|
|
Term
| Which drugs cause akathisia? |
|
Definition
| aripiprazole, asenapine, lurasidone |
|
|
Term
| Which drugs affect blood sugar levels? |
|
Definition
| hyperglycemia: olanzapine & lurasidone; quetiapine less pronounced than lanzapine |
|
|
Term
| which drugs cause weight gain? |
|
Definition
| most, but especially: olanzapine, quetiapine, clozapine |
|
|
Term
| Which drugs have off-label/additional use for autism? Which one for irritability and aggression in autism? |
|
Definition
| Quetiapine (o/l), aripirazole, and Risperidone (for the irritability & aggression) |
|
|
Term
| which drug is also used for the depressive episodes of bipolar? |
|
Definition
|
|
Term
| which meds will cause sedation? |
|
Definition
|
|
Term
| With IM Risperidone (Consta), overlap for ____ and give ____ with first injection if switching TO. If switching from depot to SA, give short acting _______ next scheduled depot inj. |
|
Definition
| 3 weeks, oral; in place of |
|
|
Term
| ______ are good for acute mania, BPD maintenance, and depression? |
|
Definition
|
|
Term
| In renal impairment, how must paliperidone's dosing be adjusted? |
|
Definition
| 50-79: max 6mg/d; 10-49: max 3 mg/d; <10: Not recommended. |
|
|
Term
| Olanzapine is also available in ____ dosage forms. |
|
Definition
|
|
Term
| which medication has a recommended titration schedule? What is that schedule? |
|
Definition
| Iloperidone; 2 mg increments q24h on days 2-7 |
|
|
Term
| which medication is least likely to cause tardive dyskinesia? |
|
Definition
|
|
Term
| What is the monitor schedule for Clozapine? What is monitored? |
|
Definition
| weekly 1st 6 mos, biweekly next 6 mos, monthly after 1st year. WBC and ANC is monitored (must be>3500 & >2000, respectively) |
|
|
Term
|
Definition
| SODAMy - Seizures, Orthostatic Hypotn, Dementia, Agranulocytosis, Myocarditis |
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