Term
|
Definition
Abilify
T, ODT, L, I
QD
Category C
CYP 2D6, 3A4 substrate
Weight gain (BMI <23)
Agitation due to activating effect hence start with low dose |
|
|
Term
|
Definition
Saphris
SL tablet only
BID
Category C
CYP 1A2 substrate
Insomnia or Somnolence, prolonged QTc
risk of neutropenia, leukopenia, agranulocytosis
|
|
|
Term
|
Definition
Clozaril, FazaClo
T, ODT
BID (Dose above 600 inc risk of seizures)
Category B
CYP 1A2 (Major), 3A4/2C19 (Minor)
(ritonavir + clozapine - C/I)
Hypersalivation, orthostatic hypotension, excessive wt gain
BBW: Agranulocytosis, Myocarditis, Seizures
|
|
|
Term
|
Definition
ANC = #WBC x (%segs + %bands)
ANC = #WBC - (#bands + #segs) |
|
|
Term
Risk Factors and Signs/Symptoms of
Agranulocytosis |
|
Definition
Risk Factors:
- Increased age
- Female gender
- Low initial WBC
Signs/Sxs:
Fever, malaise, fatigue, chills, myalgias, arthralgias
Sxs resolve within 2 weeks after stopping clozapine as long as infection is avoid |
|
|
Term
|
Definition
Fanapt
T
BID
Category C
CYP3A4 (Major), 2D6 (Minor)
hyperprolactinemia, QTc prolongation |
|
|
Term
|
Definition
Latuda
T
QD w/ food!
Category B
CYP3A4
Somnolence,akastesia, nausea, parkinsonism, agiation |
|
|
Term
|
Definition
Zyprexa, Zyprexa Relprevv (IM XR), Zydis
T, IM SA, ODT, IM XR
QD
Category C
CYP 1A2 (major), 2D6 (minor)
Smoking (inducer) - dec olanzapine conc by 40%
Sedation, weight gain, increased BG levels, TGs, & cholesterol
|
|
|
Term
|
Definition
Invega, Invega Sustenna
ER, Long Acting Inj, Suspension
QD
Category C
CYP 2D6/3A4
Sedation, dizziness, increased prolactin levels, increased BG, weight gain - QTc prolongation?
All product are XR
|
|
|
Term
|
Definition
Risperidal, Consta
T, ODT, Inj, LAI
BID (Dose above 8mg/day loses atypical appearance)
Category C
CYP 2D6 (Major), 3A4 (Minor)
Weight gain and increased BG levels (less than olanzapine, quetiapine, and clozapine), hyperprolactinemia
|
|
|
Term
|
Definition
Seroquel
T, ER
IR: BID, ER: QD
Category C
CYP3A4 (major), 2D6 (minor)
Somnolence, agitaiton, weight gain, dizziness, orthostatic hypotension, increased TGs and BG |
|
|
Term
|
Definition
Geodon
C, Inj
BID
Category C
aldehyde oxidase, CYP 3A4/1A2 (minor)
no increase in prolactin levels, weight neutral, QTc prolongation, hypomagnesemia, hypokalemia |
|
|
Term
|
Definition
Aripiprazole
Lurasidone
Olanzapine
Paliperidone
Quetiapine XR
"QuArLOP" |
|
|
Term
|
Definition
Asenapine
Clozapine
Iloperidone
Risperidone
Quetiapine IR
Ziprasidone
"ZAsQuIR" |
|
|
Term
|
Definition
Lurasidone
Clozapine
"LC is hot and wants babies" |
|
|
Term
|
Definition
Major:
Aripiprazole
Iloperidone
Lurasidone
Quetiapine
"QuAIL"
Minor:
Clozapine
Paliperidone
Risperidone
Ziprasidone
"CloPaRZ" |
|
|
Term
|
Definition
Major:
Aripiprazole
Iloperidone
Risperidone
"AIR"
Minor:
Olanzapine
Paliperidone
Quetiapine
"OPaQ" |
|
|
Term
|
Definition
Major:
Asenapine
Clozapine
Olanzapine
Minor:
Ziprasidone |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Risperidone, Paliperidone |
|
|
Term
|
Definition
Clozapine, Olanzapine
Aripiprazole (with BMI< 23) - not as much as others
Ziprasidone = weight neutral |
|
|
Term
|
Definition
Asenapine (Saphris)
Iloperidone (Fanapt)
Paliperidone (Invega)
Ziprasidone (Geodon) |
|
|
Term
|
Definition
|
|
Term
|
Definition
AIMS, CBC, Chemistry Profile, TFTs, Lipid Panel, HbA1C, EKG, BP, Pulse, Wt, Pregnancy Test, BMI
Quetiapine: also Eye exam
Ziprasidone: also Mg & K (Hypomagnasemia, Hypokalemia) |
|
|
Term
|
Definition
| Resolution of EPS, Chemistry Profile, Pulse, Wt, BMI |
|
|
Term
|
Definition
| Lipid panel, Fasting glucose HbA1C |
|
|
Term
|
Definition
AIMS
Quetiapine: Eye Exam |
|
|
Term
|
Definition
| EKG, Chemistry Profile, TFTs, CBC |
|
|
Term
Clozapine Monitoring:
Baseline |
|
Definition
| AIMS, CBC with differential, Chemistry profile, TFTs, Lipid Panel, HbA1C, EKG, BP, Pulse, Weight, Pregnancy test |
|
|
Term
Clozapine Monitoring:
1st 2-4 weeks |
|
Definition
|
|
Term
Clozapine Monitoring:
Monthly |
|
Definition
|
|
Term
Clozapine Monitoring:
Weekly for 1st 6 months |
|
Definition
WBC + ANC, Weight
(If >5% Weight gain; FBS, Vitals, resolution of EPS) --> watch carefully |
|
|
Term
Clozapine Monitoring:
Quarterly |
|
Definition
| Lipid panel, Fasting glucose HbA1C |
|
|
Term
Clozapine Monitoring:
Bi-weekly for months 6-12 |
|
Definition
|
|
Term
Clozapine Monitoring:
Twice a Year |
|
Definition
|
|
Term
Clozapine Monitoring:
every 4 wks after 12 months |
|
Definition
|
|
Term
Clozapine Monitoring:
Annually |
|
Definition
| EKG, CBC, Chemistry Profile, TFTs |
|
|
