Term
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Definition
ranitidine HCl (Zantac)*
cimetidine (Tagamet)
famotidine (Pepcid)
block histamine receptors on parietal cells that produce stomach act: decrease acid and pH |
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Term
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Definition
omeprazole (Prisolec)*
pantaprazole (Protonix)
lansoprazole (Prevacid)
esomeprazole (Nexium)
inhibit hydrogen potassium ATPase enzyme system in parietal cells and suppress acid production |
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Term
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Definition
sucralfate (Carafate)
chemical reaction in stomach that forms a gel to coat ulcer and create barrier from secretions |
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Term
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Definition
aluminal hydroxide (Amphojel)*
Mg hydroxide (MOM)
Ca carbonate
Mg+Aluminum hydroxide (Magaldrate)
alkaline: neutralize acid |
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Term
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Definition
misoprostol (Cytotec)
endogenous prostaglandin - DEC gastric acid secretion, INC bicarb, protectant mucus, submucosal vasodilation |
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Term
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Definition
prochlorperazine (Compazine)*
promethazine (Phenergan)
metoclopramide (Reglan)
block dopamine in CTZ |
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Term
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Definition
ondansetron (Zofran)
granisetron (Granisol)
palonosetron (Aloxi)
blocks 5HT3 serotonin receptors in CTZ in brain and afferent vagal nerves that innervate the SI and stomach |
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Term
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Definition
dimenhydrinate (Dramamine)
scopolamine (Transderm SCOP)
block H1 receptors in inner ear and CTZ |
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Term
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Definition
metoclopraminde (Reglan)
dopamine receptor blocker that increases tone of esophageal sphincer, increases peristalsis and CTZ threshold |
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Term
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Definition
psyllium (Metamucil)
Ca polycarbophil (Fiberlon)
methycellulose (Citrucel)
bulk forming lax - absorbed int. water, stretches wall |
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Term
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Definition
docusate Na (Colace)
docusate Na and senna (peri-colace)
sufactant lax 0 change surface tension
INC water into stool
stim wall and colon motility |
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Term
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Definition
bisacodyl (Ducolax)
senna (Senokot, Ex-lax)
Castor oil
Cascara sagrada
stim untestinal motility of colon
wall DEC fluid absorption and INC secretion |
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Term
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Definition
diphenoxylate/atropine (Lomotil)
loperamide (Imodium)
DEC peristalsis = INC transit time = INC water of feces = harder and less |
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Term
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Definition
Alosetron (Lotonex)
blocks serotonin 5HTCZ receptions and slows peristalsis, DEC sec and DEC visceral pain |
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Term
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Definition
lubiprostone (Amitza)
serotonin 5HT4 agonist
DEC viseral pain
INC peristalsis
INC sec
activate chloride channels |
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Term
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Definition
sulfasalazine (Azulfidine)
mesalamine (Asacol Rowasa)
prostaglanin inhibitor DEC inflammation in intestines |
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Term
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Definition
azathioprine (Imuran)
cyclosporine (Sandimmune)
Methotrexate (Rheumatrex)
inhibit B and T lymph, DEC immune response |
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