Term
| How do beta ags treat asthma |
|
Definition
| Gs-AC-cAMP-reduces myosin light chain phosphorylation-hyperpolarize smooth muscles |
|
|
Term
|
Definition
| albuterol, levalbuterol, terbutaline, and pirbuterol |
|
|
Term
|
Definition
prophylaxis of exercise induced asthma
COPD |
|
|
Term
| This is given subcu when a severe asthma attack limits admin of aerosols |
|
Definition
|
|
Term
|
Definition
salmeterol
NO anti-inflammatory action |
|
|
Term
| What is the SNP in beta 2 receptor |
|
Definition
|
|
Term
| when should ipratropium and tiotropium be used |
|
Definition
| COPD, where constriction is due to vagal tone instead of asthma |
|
|
Term
| What type of receptors to anticholinergics target? |
|
Definition
|
|
Term
| Which has fewer side effects, atropine or Ipra and tio |
|
Definition
| Ipra and Tio (aerosol form) |
|
|
Term
| What is it exactly that anticholi's inhibit |
|
Definition
| Ach-induced bronchoconstriction |
|
|
Term
| What are anticholi's ineffective at |
|
Definition
| reducing airway mucus secretion |
|
|
Term
|
Definition
blurred vision
eye pain
difficulty urinating |
|
|
Term
| This asthma drug inhibits phosphodiesterase causing decrease in T cells and eosinophils |
|
Definition
|
|
Term
| Examples of methylxanthines |
|
Definition
| theophylline and caffeine |
|
|
Term
| When should theophylline be used |
|
Definition
| to add quality of life either in asthma or COPD |
|
|
Term
| What effects do methylxanthines play on the diaphragm? |
|
Definition
| reduce fatigue (more in COPD) |
|
|
Term
| How do corticosteroids decrease asthma |
|
Definition
decrease inflammatory protein transcription
inhibit IL-4 and 5
reducing IgE production by B cells and eosinophils
induce apoptosis of eosinophils and Th2 lymphocytes |
|
|
Term
| These two corticosteroids are NOT subjected to first pass metabolism in the liver |
|
Definition
| beclomethasone and triamcinolone |
|
|
Term
|
Definition
Beclomethasone
fluticasone |
|
|
Term
|
Definition
voice change
cadidisasis (Beclomethasone)
impaired glucose control in diabetes |
|
|
Term
| These drugs stabilize mast cell responses |
|
Definition
|
|
Term
| cromolyn and nedocromil are administered to do |
|
Definition
reduce acute exercise induced asthma
reduce chronic inflammation |
|
|
Term
| When are mast cell stabilizers effective? |
|
Definition
when steroid use in contraindicated
reducing symptoms of allergic rhinoconjuctivitis |
|
|
Term
| what does zileution inhibit |
|
Definition
| 5-lipoxygenase, blocking arachidonic acid into leukotriene A4 |
|
|
Term
|
Definition
|
|
Term
| This leuko inhib is used once a day |
|
Definition
|
|
Term
| What are leuko inhibs used as an alternative for? |
|
Definition
| low dose inhaled steroids for control of mild chronic asthma |
|
|
Term
| Montelukast and zafirlukast have been associated with what disease |
|
Definition
| Severe granulomatous vasculitis aka Churg-Strauss syndrome |
|
|
Term
| toxic effect os zafirlukast |
|
Definition
|
|
Term
|
Definition
| increased liver transaminase levels |
|
|
Term
| what is the function of Omalizumab |
|
Definition
|
|
Term
| when is Omali most effective |
|
Definition
high corticosteroid requirement, and frequent exacerbations.
Treats severe asthma |
|
|
Term
|
Definition
|
|
Term
| What do LABAs have to be used in conjunction with? |
|
Definition
|
|
Term
| Toxicities of Anticholinergics |
|
Definition
|
|
