Term
|
Definition
Inhalation Anesthetic;
Analgesia, but not full anesthetic;
Maintenance of protective reflexes;
cheaper - "vapor sparing";
SE - potential teratogen, drowsiness, dizziness, vertigo, dysphorya, panic, amnesia, laughing, parasthesias |
|
|
Term
|
Definition
Liquid Inhalation Anesthetic;
3rd (of 3) agent of choice;
SE - arrhythmias (esp w/ CA), hepatotoxicity (halothane hepatitis), loss of reflexes, hypovent, CV depression |
|
|
Term
|
Definition
Liquid Inhalation Anesthetic;
2nd agent of choice;
SE - areflexia, irritant, muscle relaxation, SEIZURES, hepatic tox, hypovent, CV depression |
|
|
Term
|
Definition
Liquid Inhalation Anesthetic;
'1st' agent of choice;
SE - areflexia, irritant, muscle relaxation, hypovent |
|
|
Term
|
Definition
Liquid Inhalation Anesthetic;
'1st' agent of choice - newer;
Accumulate and equilibrate quickly, PLUS rapid recovery;
SE - areflexia, irritant, hypovent |
|
|
Term
|
Definition
Liquid Inhalation Anesthetic;
'1st' agent of choice - newer;
Accumulate and equilibrate quickly, PLUS rapid recovery;
SE - areflexia, hypovent, CV depression |
|
|
Term
|
Definition
Induction agent;
Barbiturate - prolong binding of GABA to GABA receptor;
Shifts endogenous GABA curve L;
No analgesic activity;
SE - Resp depression, death, bronchospasm, interactions lead to CV effects |
|
|
Term
|
Definition
Induction agent;
Barbiturate - prolong binding of GABA to GABA receptor;
Shifts endogenous GABA curve L;
No analgesic activity;
SE - Resp depression, death, bronchospasm, interactions lead to CV effects |
|
|
Term
|
Definition
Induction agent;
Inc GABA activity, dec Glu activity, RAPID;
No analgesia;
Sedation, antiemetic, dec ICP;
SE - dec CBF, CO, RR, P INFUSION SYNDROME |
|
|
Term
|
Definition
Induction agent;
Inc GABA's action, may displace endogenous antagonists;
Potent cerebral vasoconstrictor;
Good drug for pt with CV problems;
SE - injection pain, inhibiton of steroidogenesis (dec HPA axis), dec CBF;
no prolonged use |
|
|
Term
|
Definition
Inhibits Glu receptor, specific CNS depression;
Balanced anesthesia;
IV and IM;
Potent analgesic, stimulate Symp NS, bronchodilator;
Dissociated state - eyes can remain open;
SE - hallucinations (use short acting BZ to control after sedation), inc CBF, inc MAP, inc CO |
|
|
Term
|
Definition
Benzodiazepine - balanced anesthesia;
Inc activity of GABA receptor/channel;
Death from OD more diff than with barbs;
No analgesia;
Anticonvulsant, anterograde amnesia, balancing sympathomimetic effects, wide safety margin;
SE - prolonged sedation, long 1/2 life;
(Flumazenil = specific BZ antagonist) |
|
|
Term
|
Definition
Benzodiazepine - balanced anesthesia;
Inc activity of GABA receptor/channel;
Death from OD more diff than with barbs;
No analgesia;
Anticonvulsant, anterograde amnesia, balancing sympathomimetic effects, wide safety margin;
(Flumazenil = specific BZ antagonist) |
|
|
Term
|
Definition
Benzodiazepine - balanced anesthesia;
Inc activity of GABA receptor/channel;
Death from OD more diff than with barbs;
No analgesia;
Anticonvulsant, anterograde amnesia, balancing sympathomimetic effects, wide safety margin;
(Flumazenil = specific BZ antagonist) |
|
|
Term
|
Definition
Local anesthetic - amide;
Injectable;
Block Na channels, inc refractory period;
Most commonly used form;
Rapid onset, intermediate duration;
ALSO... Rapid seq intubation- dec intracranial and bronchospastic response |
|
|
Term
|
Definition
Local anesthetic - amide;
Injectable;
Block Na channels, inc refractory period;
No topical effects;
Slow onset, intermediate duration |
|
|
Term
|
Definition
Local anesthetic - amide;
Injectable;
Block Na channels, inc refractory period;
Rapid onset, intermediate duration;
Dec acute tox;
SE - Methemoglobinemia (Ferric Hb, cyanosis) |
|
|
Term
|
Definition
Local anesthetic - amide;
Injectable;
Block Na channels, inc refractory period;
Slow onset, LONG duration;
Very potent due to long binding |
|
|
Term
|
Definition
Local anesthetic - amide;
Injectable;
Block Na channels, inc refractory period;
Slow onset, LONG duration;
Very potent due to long binding;
Dec cardiotoxicity |
|
|
Term
|
Definition
Local anesthetic - ester;
Injectable;
Block Na channels, inc refractory period;
Slow onset, short duration;
Standard used to measure potency of other agents |
|
|
Term
| Chloroprocaine (Nesacaine) |
|
Definition
Local anesthetic - ester;
Injectable;
Block Na channels, inc refractory period;
Block Na channels, inc refractory period;
Rapid onset, SHORTEST duration (1/2 life);
Minimal fetal exposure |
|
|
Term
|
Definition
Local anesthetic - ester;
Injectable;
Block Na channels, inc refractory period;
Slow onset, long action;
HIGH POTENCY;
Potentially very toxic |
|
|
Term
|
Definition
Local anesthetic - ester;
Injectable, topical ENT use;
Block Na channels, inc refractory period;
Potent vasoconstriction;
SE - cardiac arrhythmias (esp w/ epi), ischemia and gangrene in nasopharynx |
|
|
Term
|
Definition
Local anesthetic - ester and amide!; Injectable;
Block Na channels, inc refractory period;
Fast onset, intermediate duration;
Dental use w/ epi; Good penetration into BONE;
SE - PARASTHESIAS |
|
|
Term
|
Definition
TOPICAL local anesthetic;
Causes swelling of membrane, occlusion of Na channels;
Often for Mucous membranes (contra to Nagel);
SE - methemoglobinemia |
|
|
Term
|
Definition
TOPICAL local anesthetic;
Block Na channels, inc refractory period;
Often for Mucous membranes (contra to Nagel); |
|
|
Term
|
Definition
TOPICAL local anesthetic;
Block Na channels, inc refractory period;
Skin use, NOT mucus membranes (contra to Nagel); |
|
|
Term
|
Definition
TOPICAL local anesthetic;
Block Na channels, inc refractory period;
Skin use, NOT mucus membranes (contra to Nagel); |
|
|
Term
|
Definition
Common ER prep;
Topical;
Prilocaine + Lidocaine;
apply, wrap, wait, wipe, proceed |
|
|
Term
|
Definition
Common ER prep;
Topical, Apply through CUT SKIN; |
|
|
Term
|
Definition
alpha-1,2 Antagonist;
used to reverse vasoconstriction |
|
|
Term
|
Definition
| Infusion of lipid emulsion ot treat severe cardiotoxicity (et. al) of local/regional anesthetics |
|
|
Term
|
Definition
H1 antagonist - anti-emetic;
Anti-dopamine, anti-cholinergic;
Tx for peri-op sedation, migraine anti-emetic;
Sedative;
SE - dec threshold for seizures, respiratory depression, glaucoma, BPH |
|
|
Term
|
Definition
H1 antagonist;
po and IM;
SEDATIVE, antichilinergic, antiemetic |
|
|
Term
| Diphenhydramine (Benadryl) |
|
Definition
H1 anti-histamine;
po and IM;
SEDATIVE, ANTICHOLINERGIC, antiemetic |
|
|
Term
|
Definition
H2 antagonist;
"no" CNS sedation;
Will neutralize the pH of gastric acid secretions, no effect on pre-existing acid level/content |
|
|
Term
|
Definition
H2 antagonist;
"no" CNS sedation;
Will neutralize the pH of gastric acid secretions, no effect on pre-existing acid level/content |
|
|
Term
|
Definition
Non-particulate Antacid;
Na- and K-citrate + citric acid;
Neutralize existing contents of stomach |
|
|
Term
|
Definition
Non-particulate Antacid;
Na- and K-citrate + citric acid;
Neutralize existing contents of stomach |
|
|
Term
|
Definition
Gastrokinetic, anti-emetic agent;
po and IV;
Central D2 block = anti-emetic, sedation;
Sensitizes upper GI to Ach;
Accelerate gastric emptying and peristalsis;
SE - lower seizure threshold, inc PL secretion (gynecomastia), drowsiness, confusion |
|
|
Term
|
Definition
Serotonin antagonist;
Anti-emetic;
Expensive, reserved for severe cases |
|
|
Term
|
Definition
Antibiotic, prophalyxis of infection;
Ancillary drug to anesthesia;
STAPH AND STREP |
|
|
Term
|
Definition
Antibiotic, prophalyxis of infection;
Ancillary drug to anesthesia;
BOWEL ANEROBES |
|
|
Term
|
Definition
Antibiotic, prophalyxis of infection;
Ancillary drug to anesthesia;
BOWEL ANEROBES |
|
|
Term
|
Definition
Antibiotic, prophalyxis of infection;
Ancillary drug to anesthesia;
MRSA |
|
|
Term
|
Definition
Anticholinergic;
Vagolytic effects (tx bradycardia);
Pre-op ancillary agent for anesthesia;
Tx reflex bradycardia, block muscarinic anticholinesterases (NM blocker OD);
Drying of secretions;
ALSO... Rapid seq intubation- mitigates bradycardia in response to succinylcholine, children <10yrs |
|
|
Term
|
Definition
Anticholinergic;
Anti-sialogogue effect (dry secretions);
Pre-op ancillary agent for anesthesia;
Tx reflex bradycardia, block muscarinic anticholinesterases (NM blocker OD);
Drying of secretions |
|
|
Term
|
Definition
Anticholinergic;
Sedation and amnesia;
Pre-op ancillary agent for anesthesia;
Tx reflex bradycardia, block muscarinic anticholinesterases (NM blocker OD);
Drying of secretions;
Blocks pathways from inner ear;
Tx motion sickness |
|
|
Term
|
Definition
| Rapid seq intubation- dec fasciculations and mitigates ICP response to Sccinylcholine |
|
|
Term
Fentanyl (Sublimaze)
non analgesic action |
|
Definition
Rapid Sequence Intubation;
dec sympathetic response to procedure;
Indicated if inc ICP, hemorrhage, CV dz |
|
|
Term
|
Definition
Ancillary: post-op CV support;
tx hypoT;
beta effect on heart, maintains renal perfusion |
|
|
Term
| Phenylephrine (AK-Dilate) |
|
Definition
Ancillary: post-op CV support;
alpha-agonist;
tx hypoT; |
|
|
Term
| Nitroprusside (Nitropress) |
|
Definition
Ancillary: post-op CV support;
tx HTN;
vasodilation, venodilation |
|
|
Term
|
Definition
Ancillary: post-op CV support;
tx HTN;
Dec sympathetic tone - vasodilation;
Prevention of reflex tachy |
|
|
Term
|
Definition
Ancillary:
tx post-op Anaphylaxis;
Initial agent to stimulate CV, vasoconstriction; |
|
|
Term
|
Definition
Ancillary:
tx post-op Anaphylaxis;
2ndary use;
tx persistent bronchospasm |
|
|
Term
Hydrocortisone
think Post-op |
|
Definition
Ancillary:
tx post-op Anaphylaxis;
Anti-inflamm function of LT, PGs, kinins released by mast cells |
|
|
Term
| Methylprednisolone (Methacort) |
|
Definition
Ancillary:
tx post-op Anaphylaxis;
Anti-inflamm function of LT, PGs, kinins released by mast cells |
|
|
Term
| Propofol Infusion Syndrome |
|
Definition
Iatrogenic dz;
Acidosis, rhabdomyolysis, arrthymias, heart and kindey failure;
Risk factors - dec O2 delivery, prior cerebral injury;
Tx - CV stabilization |
|
|
Term
|
Definition
(review)
1st treatment - mild to moderate migraine;
SE - gastric irritation, nephrotoxicity (dec renal blood flow);
CI - G6PD deficiency and high dose aspirin |
|
|
Term
|
Definition
Barb for acute migraine tx;
GABA enhancement - sedative function;
SE - ANALGESIC OVERUSE SYN, CYP450 induction, CNS+resp depression, porphyria (beware of Nishimoto's vampireS) |
|
|
Term
|
Definition
Opiate for acute migraine tx;
Agonist/antagonist of all 3 ORs;
Hyperpolarizes endplate, dec cAMP, blocks SP release;
SE - resp depression, bradycardia, histamine release, QT prolong, constipation, CYP3A4's, N/V |
|
|
Term
Acute therapy of migraines
review (5) agents |
|
Definition
NSAIDs
Opiates
Triptans
Ergot's
(Anti-emetics) |
|
|
Term
|
Definition
Triptan for acute migraine tx (1st line);
Cerebral vasoconstriction, Inh trigeminal n activation, Inh trigeminal cervical cortes activation;
5-HT1b, 5-HT1d actions;
Met by CYP450;
Least problems with triptan SE, but..
SE - sleepiness, dec mentition, inc HR, dizziness, VASOSPASM |
|
|
Term
|
Definition
Triptan for acute migraine tx (1st line);
Cerebral vasoconstriction, Inh trigeminal n activation, Inh trigeminal cervical cortes activation;
5-HT1b, 5-HT1d actions;
Met by MAOs;
SE - sleepiness, dec mentition, inc HR, dizziness, VASOSPASM |
|
|
Term
|
Definition
Triptan for acute migraine tx (1st line);
Cerebral vasoconstriction, Inh trigeminal n activation, Inh trigeminal cervical cortes activation;
5-HT1b, 5-HT1d actions;
PO, nasal, or SC admin;
DOESN'T CROSS BBB;
Met by MAOs;
SE - sleepiness, dec mentition, inc HR, dizziness, VASOSPASM |
|
|
Term
|
Definition
Triptan for acute migraine tx (1st line);
Cerebral vasoconstriction, Inh trigeminal n activation, Inh trigeminal cervical cortes activation;
5-HT1b, 5-HT1d actions;
Met by MAOs;
SE - sleepiness, dec mentition, inc HR, dizziness, VASOSPASM |
|
|
Term
| Dihydroergotamine (Migranal) |
|
Definition
Ergot for acute SEVERE migraine tx;
Agonist on 5-HT1&2, alpha-1&2, D2;
Central and peripheral vasoconstriction;
BP is unpredictable;
SE - drug interactions, CATEGORY X, valvular heart dz;
CI - vasospasm, triptans, vasoconstrictors, tobacco, propranolol |
|
|
Term
|
Definition
Ergot for acute SEVERE migraine tx;
Agonist on 5-HT1&2, alpha-1&2, D2;
Central and peripheral vasoconstriction;
BP is unpredictable;
SE - drug interactions, CATEGORY X, valvular heart dz;
CI - vasospasm, triptans, vasoconstrictors, tobacco, propranolol |
|
|
Term
|
Definition
Anti-emetic in acute Migraine tx;
D2 block at chemoreceptors, Ach and alpha-adrenergic block;
SE - Sedation, muscle relax, hypoT, HA, glaucoma, additive CNS effects, dec seizure threshold, tardive dyskinesia |
|
|
Term
| Chlorpromazine (Thorazine) |
|
Definition
Anti-emetic in acute Migraine tx;
D2 block at chemoreceptors, Ach and alpha-adrenergic block;
SE - Sedation, muscle relax, hypoT, HA, glaucoma, additive CNS effects, dec seizure threshold, tardive dyskinesia |
|
|
Term
|
Definition
TCA for chronic migraine prophylaxis;
Inhibits NE and Sero uptake;
Anti-cholinergic;
SE - aggression, irritability, tachycardia, cycloplegia, xerostomia, constipation, urinary ret, endocrine dysfunction |
|
|
Term
|
Definition
Anticonvulsant for chronic migraine prophylaxis;
Inh Na channels, dec GABA met & reuptake;
Highly protein bound;
CYP2C9 substrate;
SE - TERATOGEN, N/V, pancreatitis, hepatotoxicity, sedation |
|
|
Term
|
Definition
Anticonvulsant for chronic migraine prophylaxis;
Inh Na channels, dec GABA met & reuptake;
Highly protein bound;
CYP2C9 substrate;
SE - TERATOGEN, N/V, pancreatitis, hepatotoxicity, sedation |
|
|
Term
|
Definition
for chronic migraine prophylaxis;
Prevents vasodilation, dec renin, dec PG synth, inc O2 delivery;
EFFECTIVE FOR CHILDREN;
SE - lethargy, GI, exercise intolerance;
CI - asthma, AV block, sinus bradycardia, DM |
|
|
Term
|
Definition
for chronic migraine prophylaxis;
Prevents vasodilation, dec renin, dec PG synth, inc O2 delivery;
SE - lethargy, GI, exercise intolerance;
CI - asthma, AV block, sinus bradycardia, DM |
|
|
Term
|
Definition
Antiepileptic for chronic migraine prophylaxis;
Block Na channel, enhance GABA, Inh Glu;
Long duration, narrow TI, renal elim; |
|
|
Term
|
Definition
for chronic migraine prophylaxis;
Inject into glabellar frontalis and temporalis mm;
Dec incidence and severity of HA;
Limited SE;
High placebo rate |
|
|
Term
|
Definition
Topical antibiotic;
Prevent clean wound infection, early tx of infected dermatoses/wounds, prevent staph in nares, tx acne vulgaris, axillary deodorizer;
Avoid in open wounds;
SE - neuro-, nephro-toxic |
|
|
Term
|
Definition
Topical antibiotic;
Prevent clean wound infection, early tx of infected dermatoses/wounds, prevent staph in nares, tx acne vulgaris, axillary deodorizer;
Limited in topical usage due to resistance fears;
SE - neuro-, nephro-, and oto-toxic |
|
|
Term
|
Definition
Topical antibiotic;
Prevent clean wound infection, early tx of infected dermatoses/wounds, prevent staph in nares, tx acne vulgaris, axillary deodorizer;
CI - pregnancy, renal, hapatic dz |
|
|
Term
|
Definition
Topical antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
Topical antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
Topical/Oral antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity;
Inh CYP2C19, 3A4,5,7!;
Inh testosterone synth |
|
|
Term
|
Definition
Topical antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
Topical antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
Topical antifungal agent - azole deriv;
Dec production of ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
| Topical antifungal agent . . . |
|
|
Term
|
Definition
Topical antifungal agent - allylamine;
Inh squalene monooxygenase to block sterol synthesis to compromise structural integrity |
|
|
Term
| Terbinafine (Desenex)(Lamisil) |
|
Definition
Topical/oral antifungal agent - allylamine;
Inh squalene monooxygenase to block sterol synthesis to compromise structural integrity;
Inh CYP2D6 as oral agent, CI - codeine, theophylline |
|
|
Term
|
Definition
Topical antifungal agent - allylamine;
Inh squalene monooxygenase to block sterol synthesis to compromise structural integrity |
|
|
Term
| Tolnaftate (Absorbine)(Tinactin) |
|
Definition
| Topical antifungal agent - thiocarbamate; |
|
|
Term
|
Definition
Topical antifungal agent - polyene;
Binds to ergosterol to compromise fungal cell wall integrity; |
|
|
Term
|
Definition
Topical antifungal agent - polyene;
Binds to ergosterol to compromise fungal cell wall integrity; |
|
|
Term
Griseofulvin (Fulvicin)
recall the major SE's (6) |
|
Definition
Oral antifungal agent;
Disrupts mitotic spindle structure, so metaphase arrest;
SE - leukopenia, proteinuria, dec anticoag effect of warfarin, dec contraceptive effects, dec cyclosporine serum lvls, inc ethanol effects |
|
|
Term
|
Definition
Oral antifungal agent;
Dec production of ergosterol to compromise fungal cell wall integrity;
Inh CYP2C9 |
|
|
Term
|
Definition
Oral antifungal agent;
Dec production of ergosterol to compromise fungal cell wall integrity;
Inh CYP3A4,5,7 |
|
|
Term
|
Definition
Very potent topical steroid;
Dec phospholipase A2 activity to dec inflamm mediators;
Immunomodulatory, anti-inflamm, antipruritic, vasoconstrictive;
Acute control;
Don't use on face, neck, groin;
SE - spread the infection, skin atrophy, glaucoma, hirsutism, acne, depigmentation, perioral dermatitis, cushingoid |
|
|
Term
|
Definition
Potent topical steroid;
Dec phospholipase A2 activity to dec inflamm mediators;
Immunomodulatory, anti-inflamm, antipruritic, vasoconstrictive;
Acute control;
Don't use on face, neck, groin;
SE - spread the infection, skin atrophy, glaucoma, hirsutism, acne, depigmentation, perioral dermatitis, cushingoid |
|
|
Term
| Betamethasone valerate (Beta-Derm) |
|
Definition
Moderate topical steroid;
Dec phospholipase A2 activity to dec inflamm mediators;
Immunomodulatory, anti-inflamm, antipruritic, vasoconstrictive;
Maintenance control;
SE - spread the infection, skin atrophy, glaucoma, hirsutism, acne, depigmentation, cushingoid |
|
|
Term
|
Definition
Mild topical steroid;
Dec phospholipase A2 activity to dec inflamm mediators;
Maintenance control;
SE - spread the infection, skin atrophy, glaucoma, hirsutism, acne, depigmentation, cushingoid |
|
|
Term
| Methylprednisolone (Solu-Medrol) |
|
Definition
IM steroid;
Dec phospholipase A2 activity to dec inflamm mediators;
Tx resistant pyoderma gangrenosum, SLE, dermatomyositis |
|
|
Term
|
Definition
Topical/Oral Calcineurin blocker;
Blocks NFAT production, dec inflamm cytokines leading to dec T-, B-cell activation;
Tx atopic dermatitis;
SE - at CYP3A4 |
|
|
Term
|
Definition
TOPICAL Calcineurin blocker;
Blocks NFAT production, dec inflamm cytokines leading to dec T-, B-cell activation;
Tx atopic dermatitis;
SE - rxn w/ alcohol |
|
|
Term
|
Definition
TOPICAL immunosuppresant;
Unknown mech;
Tx external genital or perianal HPV warts; |
|
|
Term
|
Definition
IV/IM fusion protein - Immunosuppressant;
Modulates CD2 response, induces apoptosis of CD2+ cells;
Tx chronic plaque psoriasis;
SE - lymphopenia, secondary BCC or SCC, neutralizing Abs |
|
|
Term
|
Definition
Tx scabies and pediculosis - 2nd line;
Topical;
Absorbed into the parasites;
SE - seizures and death, CNS stimulant |
|
|
Term
|
Definition
Tx scabies and pediculosis;
Topical;
Unknown mech;
Avoid inflamed or raw skin; |
|
|
Term
|
Definition
Tx scabies and pediculosis - 1st line;
Topical;
Na channel disrupter = parasite death;
SE - none (low absorption + systemic inactivation) |
|
|
Term
|
Definition
Tx resistant scabies and pediculosis;
Remember: acetylcholinesterase inhibitor (insecticide);
SE - systemic ingestion=cholinergic effects |
|
|
Term
|
Definition
1ST Generation Retinoid - Oral;
Bind RAR, inc RNA pol activity, dec epidermal cohesion, inc epidermal cell turnover;
Tx inflamm dz's, hyperprolif dz's, skin malignancies;
Enhance penetration of other agents (benzoyl peroxide, topical ABs);
SE - dry skin, nose bleeds, conjunctivitis, alopecia, PHOTOSENSITIVITY, TERATOGEN |
|
|
Term
|
Definition
1ST Generation Retinoid - Oral;
Bind RAR, inc RNA pol activity, dec epidermal cohesion, inc epidermal cell turnover;
Tx inflamm dz's, hyperprolif dz's, skin malignancies;
Enhance penetration of other agents (benzoyl peroxide, topical ABs);
SE - dry skin, nose bleeds, conjunctivitis, alopecia, PHOTOSENSITIVITY, TERATOGEN |
|
|
Term
|
Definition
2ND Generation Retinoid - Oral;
Bind RAR, inc RNA pol activity, dec epidermal cohesion, inc epidermal cell turnover;
Tx inflamm dz's, hyperprolif dz's, skin malignancies;
Enhance penetration of other agents (benzoyl peroxide, topical ABs);
SE - dry skin, nose bleeds, conjunctivitis, alopecia, PHOTOSENSITIVITY, TERATOGEN |
|
|
Term
|
Definition
3RD Generation Retinoid - TOPICAL;
Bind RAR, inc RNA pol activity, dec epidermal cohesion, inc epidermal cell turnover;
Tx inflamm dz's, hyperprolif dz's, skin malignancies;
Enhance penetration of other agents (benzoyl peroxide, topical ABs);
SE - dry skin, nose bleeds, conjunctivitis, alopecia, PHOTOSENSITIVITY, TERATOGEN |
|
|
Term
|
Definition
3RD Generation Retinoid - TOPICAL;
Bind RAR, inc RNA pol activity, dec epidermal cohesion, inc epidermal cell turnover;
Tx inflamm dz's, hyperprolif dz's, skin malignancies;
Enhance penetration of other agents (benzoyl peroxide, topical ABs);
SE - dry skin, nose bleeds, conjunctivitis, alopecia, PHOTOSENSITIVITY, TERATOGEN |
|
|
Term
|
Definition
Topical;
Oxidation of bacterial proteins, keratolytic for acne resolution;
Tx. - P. acnes in seb. follicles and comedones;
SE - Xerosis, skin irritation, sting, +Hydroquinone= dark staining |
|
|
Term
|
Definition
Keratolytic - topical;
Anti-microbial, anti-keratinizing, anti-inflamm;
Reversible inh of DNA pol, tyrosinase, resp mitochondrial enzymes; |
|
|
Term
|
Definition
| Keratolytic - topical; Solubilization of cell surface protein; SE - salicylism and death (tx w/ dialysis), Contact/allergic dermatitis (urticaria, anaphylaxis, erythema multiforme) |
|
|
Term
|
Definition
Keratolytic - topical;
SE - contact dermatitis |
|
|
Term
|
Definition
(Rogaine) - topical, Trichogenic;
Inh PDE, SM contriction(?), vasodilation;
Tx hair loss;
SE - hypotension;
Avoid use at skin abrasion |
|
|
Term
|
Definition
Oral trichogenic;
Block DHT production;
Tx hair loss;
SE - sexual dysfunction;
CI w/ Saw palmetto |
|
|
Term
|
Definition
Topical Anti-trichogenic;
Unknown mech, releated to ODC lvls;
Tx unwanted facial hair |
|
|
Term
| Hydroquinone (+Fluocinolone/Tretinoin=Tri-Luma) |
|
Definition
Pigmentation agent;
Inh melanocyte production of DOPA, melanin formation;
Tx facial skin darkening 2nd to hormonal changes |
|
|
Term
|
Definition
Oral/Topical Pigmentation agent;
Stimulate melanocytes;
Tx vitiligo, psoriasis, cutaneous lymphoma, alopecia, inflamm dermatoses, eczema, lichen planus;
SE - +UV=erythema&inc melanin&cytotoxic, photosensitivity |
|
|
Term
| Drugs/classes that induce anaphylaxis (8) |
|
Definition
barbiturates
etomidate
ester-type local anesthetics
succinylcholine
meperidine
morphine
fentanyl
antibiotics |
|
|
