Term
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Definition
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Term
M1 receptor
post-receptor mechanism |
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Definition
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Term
|
Definition
| heart, nerves, smooth muscle |
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Term
M2 receptor
post-receptor mechanism |
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Definition
inhibition of cAMP production;
activation of K+ channels |
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Term
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Definition
| glands, smooth muscle, endothelium |
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Term
M3 receptor
post-receptor mechanism |
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Definition
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Term
M4 receptor
post-receptor mechanism |
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Definition
inhibition of cAMP production
(like M2) |
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Term
M5 receptor
post-receptor mechanism |
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Definition
| Na+, K+ depolarizing ion channel |
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Term
|
Definition
| inhibits fusion of ACH vesicles at presynaptic membrane; degradation of VAMPs and SNAPs; clinical uses: facial wrinkles, strabismus, blepharospasm (abnormal movement or twitch of the eye lid), Meige's syndrome, spasmodic toricollis, other muscle spasms |
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Term
|
Definition
inhibits choline transport into neuron to inhibit ACH synthesis;
rate-limiting step |
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Term
|
Definition
| inhibition of nerve impulses at Na+ channels |
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Term
|
Definition
inhibitor of synthesis, release of ACH;
false neurotransmitter; |
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Term
|
Definition
no tx uses;
can be used to test for miosis after surgery;
doesn't cross BBB;
small dose will lead to release of NO and decrease of BP;
large dose - direct effect on M2 dec BP, also acts at sympathetic ganglia and adrenal medulla (both N1), at NMJ contraction of skeletal muscle |
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Term
|
Definition
M agonist; no N action!
no effects w/ atropine (complete block);
tx urinary retention and post-op bowel; |
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Term
|
Definition
M agonist; some action on N
tx urinary retention and post-op atonic bowel; |
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Term
|
Definition
M agonist; no N actions!
oral admin;
tx [dry mouth] Sjogren's, Mikulicz's, and Sicca syndromes;
effects blocked by atropine; |
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Term
|
Definition
M agonist; some N action
DX asthma;
give with atropine to increase BP |
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Term
|
Definition
M agonist; no N action!
synthetic alkaloid;
tx closed-angle glaucoma, applied topically to increase outflow of aqueous humor |
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Term
|
Definition
BLOCKS M RECEPTORS;
tx- dec secretions for endotrach tube, acute MI, digitalis toxicity |
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Term
|
Definition
M antagonist;
tx parkinson's |
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Term
|
Definition
M antagonist;
tx dec gastric hypermotility |
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Term
|
Definition
M antagonist;
tx asthma, COPD;
inhaled, won't absorb in GI;
won't cross BBB |
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Term
|
Definition
M antagonist;
tx motion sickness;
lipid soluble, can cross BBB |
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Term
|
Definition
M antagonist;
tx parkinson's |
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Term
|
Definition
M antagonist;
examination of fundus;
shorter duration than atropine; |
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Term
|
Definition
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Term
|
Definition
M antagonist;
tx inhibit hyperactive bladder |
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Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
Binds N1 and N2;
increase HR, then decrease (if large dose);
stimulation of skeletal m;
release ADH in CNS (plus others) |
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Term
|
Definition
N1 antagonist, not used clinically;
won't cross BBB (quat ammonium cpd) |
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Term
|
Definition
N1 antagonist, used clinically;
crosses BBB;
tx severe HTN, Tourette's Syndrome;
side effects- impotence, CNS effects |
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Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset;
spontaneous Hoffman degradation and by plasma choliesterases;
CV effects due to histamine release |
|
|
Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset, long duration;
histamine release may cause hypoT;
tx- muscle relax with gen anesthetics, convulsive disorders |
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|
Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset, short duration;
degraded by pseudocholinesterase |
|
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Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset, long duration;
tx muscle relaxant for endotrach intubation;
renal/hepatic degradation |
|
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Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset;
renal/hepatic degradation |
|
|
Term
|
Definition
non-depolarizing neuromuscular blocker;
short onset;
hepatic/renal degradation |
|
|
Term
|
Definition
depolarizing neuromuscular blocker;
rapid onset, short duration;
histamine release, SA node M receptors and autonomic ganglia fx (=CV effects);
2 phases, first depolarizing activator, second desensitized block |
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Term
|
Definition
| reversible anticholinesterase inhbitor; DX MG; rapid onset, short duration; stimulation skeletal m by direct action |
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Term
|
Definition
| reversible anticholinesterase inhbitor; dx and tx MG; tx post-op bladder and bowel atony; can reverse non-depol NM blockers |
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Term
|
Definition
| reversible anticholinesterase inhbitor; tx glaucoma, atropine O.D., dimentia, and Alzheimer's; crosses BBB, CNS stim then depression |
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Term
|
Definition
| reversible anticholinesterase inhbitor; tx MG; some direct action on N2; long lasting; |
|
|
Term
|
Definition
| irreversible anticholinesterase inhbitor; tx glaucoma; organophosphorous cpd; long duration; can cause cataracts |
|
|
Term
|
Definition
| irreversible anticholinesterase inhbitor |
|
|
Term
|
Definition
| irreversible anticholinesterase inhbitor |
|
|
Term
|
Definition
| irreversible anticholinesterase inhbitor |
|
|
Term
|
Definition
| irreversible anticholinesterase inhbitor |
|
|
Term
|
Definition
| reactivator of acetylcholinesterase; tx O.D. of irreversible anticholinesterase inhbitors |
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Term
|
Definition
| inhibition of nerve impulses at Na+ channels |
|
|
Term
| contraindications of M agonists (4) |
|
Definition
asthma;
hyperthyroid - atrial fib;
coronary insufficiency - hypoT;
peptic ulcer dz |
|
|
Term
Atropine
contraindications |
|
Definition
|
|
Term
| Mecamylamin contraindications (3) |
|
Definition
| renal, cerebrovscular, and coronary insufficiency |
|
|
Term
|
Definition
| blocks the packaging of ACH into vesicles |
|
|
Term
|
Definition
stimulated by ACH/muscarine; blocked by atropine;
important locations include SM on blood vessels, and sweat glands |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Diisopropyl flurophosphate (DFP) |
|
Definition
| irreversible anticholinesterase |
|
|
Term
|
Definition
| irreversible anticholinesterase |
|
|
Term
|
Definition
| irreversible anticholinesterase |
|
|
Term
|
Definition
| irreversible anticholinesterase |
|
|
Term
|
Definition
| irreversible anticholinesterase |
|
|
Term
|
Definition
iris sphincter m - contraction
ciliary m - contraction (near vision) |
|
|
Term
|
Definition
|
|
Term
M on atria (heart)
3 actions |
|
Definition
dec contractile strength (iontropy)
dec absolute refractory period
inc conduction velocity |
|
|
Term
|
Definition
dec conduction velocity (dromotropy)
inc relative refractory period |
|
|
Term
|
Definition
| dec (small) in contractile strength |
|
|
Term
|
Definition
arteries - dilation (NO production);
veins - dilation (NO production) |
|
|
Term
|
Definition
bronchial m - contraction
bronchial glands - stim secretion |
|
|
Term
|
Definition
generally, inc motility
sphincters - relaxation
secretion - stimulation |
|
|
Term
|
Definition
detrussor - contraction
trigone and sphincter - relaxation |
|
|
Term
|
Definition
(sweat, salivary, lacrimal, nasopharyngeal)
stim secretion |
|
|
Term
| Ganglionic antagonist on arterioles |
|
Definition
|
|
Term
| Ganglionic antagonist on veins |
|
Definition
tone: S(A);
dilation w/ dec venous return |
|
|
Term
| Ganglionic antagonist on heart |
|
Definition
|
|
Term
| Ganglionic antagonist on iris |
|
Definition
|
|
Term
| Ganglionic antagonist on ciliary muscle |
|
Definition
cycloplegia
loss of accommodation |
|
|
Term
| Ganglionic antagonist on GI tract |
|
Definition
dec tone and motility;
constapation |
|
|
Term
| Ganglionic antagonist on urinary bladder |
|
Definition
|
|
Term
| Ganglionic antagonist on salivary gland |
|
Definition
|
|
Term
| Ganglionic antagonist on sweat gland |
|
Definition
|
|
Term
|
Definition
| a cyclodextrin derivative that binds the steriodal neuromuscular blocking agent |
|
|
Term
|
Definition
inhalational anesthetics; curare-like action;
enhance competitive NM blockers |
|
|
Term
|
Definition
inhalational anesthetics;
curare-like action;
enhance competitive NM blockers |
|
|
Term
| Two drugs used in Anticholinesterase O.D. |
|
Definition
Tremethadone
Thiopental
(+ Atropine and Pralidoxime) |
|
|
Term
|
Definition
| cholinesterase reactivator |
|
|
Term
|
Definition
non-depolarizing and depolarizing NM antagonist!;
also has anticholinesterase activity |
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