Term
| Arachidonic acid (lipoxygenases) |
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Definition
HPETE -> 1. Leukotrienes
2. HETE
3. Lipoxins |
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Term
| Arachidonic acid (cyclooxygenase) |
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Definition
PGG2 -> 1. Prostaglandins
2. Thromboxanes
[ - aspirin and other NSAIDs] |
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Term
| Arachidonic acid (cytochrome p450) |
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Definition
Epoxides-> 1. diHETE
2. HETE |
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Term
| Stimulus binds to receptor and Arachidonic acid released from what? |
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Definition
Membrane lipid, phosphatidyl choline
[- glucocorticoids] |
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Term
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Definition
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Term
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Definition
| vasodilator and vaso constriction |
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Term
| PGI2 (prostacyclin) on cardiovasc |
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Definition
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Term
| Thromboxane on cardiovasc |
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Definition
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Term
| Leukotrienes on cardiovasc |
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Definition
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Term
|
Definition
| inhibit platelet aggregation |
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Term
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Definition
| induce platelet aggregation |
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Term
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Definition
| LTB4 is a potent chemotactic agent (direct movement) |
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Term
| prostoglandins on smooth muscle |
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Definition
| contract or releax smooth muscle |
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Term
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Definition
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Term
| PGF's on bronchial and tracheal muscle |
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Definition
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Term
| PGD2 on bronchial and tracheal muscle |
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Definition
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Term
| PGE on bronchial and tracheal muscle |
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Definition
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Term
| LTC4 on bronchial and tracheal muscle |
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Definition
| potent bronchoconstrictors |
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Term
| LTD4 on bronchial and tracheal muscle |
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Definition
| potent bronchoconstrictors |
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Term
| PGF on Uterus during pregnancy |
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Definition
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Term
| PGE on Uterus during pregnancy |
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Definition
contracts at [low]
relax at [high] |
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Term
| PGI2 on Uterus during pregnancy |
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Definition
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Term
| Responsiveness of Uterus during pregnancy |
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Definition
| increases as pregnancy progresses |
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Term
|
Definition
| contract long and circ muscle |
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Term
|
Definition
contract long
relax circ
inhibit gastric acid secretion
cytoprotective in stomach
promote healing of duodenal and gastric ulcers |
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Term
|
Definition
| inhibit gastric acid secrection |
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Term
| PG's on kidney and urine function |
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Definition
| influence renal salte and water ecretion by alterations in renal blood flow and by direct effect on renal tubules |
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Term
| PGE2 on kidney and urine function |
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Definition
increase renal blood flow, provoke diuresis, natriuresis, and kaliuresis with little change in GFR
cause secretion of renin from renal cortex by direct effect on the JG cells |
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Term
| PGI2 on kidney and urine function |
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Definition
increase renal blood flow, provoke diureses, natriuresis, and kaliuresis with litlle change in GFR
cause secretion of renin from the renal cortex by direct effect of the JG cells |
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Term
| PGD2 on kidney and urine function |
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Definition
| cuase secretion of renin from the renal cortex by a direct effect on the JG cells |
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Term
| PGE on kidney and urine function |
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Definition
| inhibit water resorption by ADH |
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Term
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Definition
cause pain when injected intradermally --afferent nerves and pain
sensitize afferent nerve endings to the effects of chemical and mechanical stimuli by lowering the threshold of the nocioreceptors |
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Term
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Definition
| sensitize afferent nerve endings to teh effects of teh chemical and mechanical stimuli by lowering the threshold of thenocioreceptors |
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Term
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Definition
| formed under inflammatory conditions causing pain and vasodilation |
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Term
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Definition
-C-20 fatty acid
-polyhroxylated, unsaturated
-5 carbon ring
-ring substitution indicate type, subscript indicate sifechain of unsaturation
-can cause smooth muscle contraction or relaxation |
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Term
|
Definition
-produced by vascular endothelial cells
-inhibits platelet aggregation
-causes vasodilation
c-20 fatty acid
-polyhydroxylated, unsaturated
-bicyclic, two 5 member rings
inhibits platelet aggregation
-brings about vasodilation |
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Term
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Definition
-produced by platelets
-stimulates platelet aggregation
-causes vasoconstriction
-C-20 fatty acid, hydroxylated, unsat
-6 member ring with an O atom as one of the members |
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Term
|
Definition
-C-20 derivatives of arachidonic acid, hydroyxlated, unsat
-may be conjugated to peptides or amino acids
-chemotactic
-causes smooth muscle contraction
-bronchoconstrictor |
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