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AP Biology
Chapter 14- From DNA to protein
22
Biology
12th Grade
05/02/2011

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Term
messenger RNA (mRNA)
Definition
the only type of RNA that carries protein-building information to ribosomes.
Term
ribosomal RNA (rRNA)
Definition
type of RNA that becomes complexed with proteins to form ribosomes, and some catalyze te assembly of polypeptide chains.
Term
transfer RNA (tRNA)
Definition
type of RNA molecule that delivers amino acids to the ribosomes. (its anticodon pairs with an mRNA codon during transation.)
Term
uracil
Definition
when associating with RNA, uracil takes the place of thymine, and can, too, pair with adenine.
Term
RNA polymerase
Definition
an enzyme that adds ribonucleotides one at a time to the end of a growing RNA strand.
Term
transcription
Definition
the first step in protein synthesis. In this process, an RNA strand is assembled from nucleotides using a gene region in DNA as a template.
Term
translation
Definition
second stage of protein synthesis. At ribosomes, information that's encoded in an mRNA transcript guides the synthesis of a new polypeptide chain from amino acid.
Term
promoter
Definition
acts as a "start" signal; a base sequence in DNA to which RNA polymerases bind and prepare for transcription. The gene's base sequence is used as a template for covalently bonding ribonucleotides together. When it reaches a sequence that signals "the end" of the gene region, the new RNA is released as a free transcript.
Term
exons/introns
Definition
exons are protein-coding base sequences that are interrupted by noncoding sequences, called introns. (Introns are snipped out before the transcript reaches the cytoplasm.)
Term
codons
Definition
the base triplets in mRNA, (bases are "read" three at a time.)
Term
anticodon
Definition
a ribonucleotide base triplet that can base-pair with complementary codons in an mRNA transcript. (There are 64 codons.) *A-T and G-C*
Term
gene mutation
Definition
Most cases happen while DNA is being replicated. Mutation does not always neccessarily mean negative outcomes, however when related with genes they are usually refered to as not beneficial. TMutation can occur when one base gets substituted for another in the nucleotide sequence. In other cases, an extra base is inserted or one is lost. These small changes to the sequence of a DNA molecule can greatly alter the message that becomes encoded in the mRNA.
Term
ionizing radiation
Definition
breaks down chromosomes into pieces. Exposure to this radiation is known to cause some types of mutation because it damages the DNA directly, penetratin living tissues and leaving behind a long trail of destructive free radicals.
Term
nonionizing radiation
Definition
excites electrons to a higher energy level. DNA absorbs one form, (UV light.) Exposing your skin to these rays causes damage and dimer formation of the skin cells.
Term
alkylating agents
Definition
transfer charged methyl or ethyl groups to reactive sites in DNA. At these sites, DNA is more vulnerable to mistakes in base-pairinf and to mutation.
Term
ricin
Definition
a deadly protein with two polypeptide chains; found in castor oil plants, a done o ricin as small as a grain of salt can kill you, because it inactivates ribosomes (the protein builders for all cells.)
Term
process to translate DNA into protein
Definition
DNA--->(transcription) RNA---> (translation) Protein
Term
alternative splicing
Definition
by this, one gene can specify two or more proteins that differ slightly in form and function. It may occur in half or all genes of the human genome.
Term
genetic code
Definition
the set of 64 different codons, (and has been highly conserevd over time.)
Term
polypeptide chains
Definition
are built on ribosomes, each consisting of a large and small subunit made of tRNA and proteins
Term
termination
Definition
the last stage o translation; the mRNA's stop codon enters the ribosome, (no tRNA has a corresponding anitcodon,) and proteins, called release factors, bind to the ribosome. Binding is what triggers the enzyme activity that detaches the mRNA and the polypetide chain from the ribosome.
Term
transposons
Definition
(or transposable elements,) are what mutations arise from, and can jump around the genome. When they lnd, they alter the timing or duration of its activity, or block it entirely.
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