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Antivirals
Antivirals
15
Pharmacology
Graduate
09/29/2009

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Cards

Term
Acyclovir
Definition
Guanine analogue, chain termination
activated by viral thymidine kinase
HSV 1,2; VZV
Term
Valacyclovir
Definition
Guanine analogue, chain terminatino
converted to acyclovir in blood
HSV 1,2; VZV
Term
famciclovir
Definition
guanine analogue, oral pro-drug of penciclovir
HSV 1,2; VZV
Term
ganciclovir
Definition
inhibits CMV DNA polymerase
chain termination
CMV
bone marrow and kidney toxic
Term
cidofovir
Definition
acyclic cytosine analogue, chain termination and inhibition of viral DNA polymerase
herpesviruses, esp. acyclovir resistant
nephrotoxic
Term
foscarnet
Definition
pyrophosphate analogue
chain termination, complex with dna polymerase
herpesviruses, esp. acyclovir resistant
Term
ribavirin
Definition
guanosine analogue
many dna and rna, RSV, Hep C, lassa fever
Term
Amantidine, Rimantidine
Definition
M2 protein of influenza A
interferes with ion channel and uncoating
insomnia, dizziness, difficulty concentrating
Term
osetamivir, zanamivir
Definition
neuraminadase inhibitor
influenza a and b
Term
interferon
Definition
glycoprotein
activates ribonuclease, inactivate initiation factor, enhance APC
chronic hep b and c
Term
NRTIs
Definition
nucleoside analogues
HIV
Term
NNRTIs (name them)
Definition
efavirenz, nevirapine, delavirdine
bind active site of reverse transcriptase
resistance develops quickly
HIV
Term
protease inhibitors (name them)
Definition
end in -navir
inhibits maturation by preventing cleavage of polyproteins
HIV
Term
T-20, enfurvirtide
Definition
fusion inhibitors
blocks conformational change in gp-41
HIV
IM injection rxn, GI intolerance, hypotension, pruritis
Term
miraviroc
Definition
CCR5 inhibitor
hepatotoxicity, cough, pyrexia, URI, rash, musculoskeletal pain, abdominal pain, dizziness
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