Shared Flashcard Set

Details

antivirals
pharmacology
12
Medical
Professional
08/26/2010

Additional Medical Flashcards

 


 

Cards

Term
Amantadine
Definition

PO; excreted in urine (unchanged)

           --requires dosage adj. for renal         impairment

uses: influenza A

-prophylactic

-can treat & vaccinate simultaneously

-initial therapy for Parkison's

 

crosses BBB -> Dopamine release

     *CNS side effects

Term
Rimantadine
Definition

PO; extensively metabolized

 

ticyclic amine (blocks viral uncoating)

 

uses: influenza A

-prophylactic

-treat and vaccinate at same time

Term
Zanamivir
Definition

inhaled; 90% urinated unchanged

 

neuraminidase inhibitor

(decr. virus relase/incr. viral aggregation)

 

uses: influenza A & B

-early admin. best (48hr)

 

-decr. influenza complications

Term
Oseltamivir
Definition

well absorbed; urinated unchanged

 

neraminidase inhibitor

(decr. viral release/incr. viral aggregation)

 

uses: influenza A & B

-best when admin early (48hr)

 

-decr. complications

-nausea/vomitting (15%)

Term

 

Ribavirin

Definition

aerosol (NOT PO)

 

nucleoside analogue

-inhib viral RAN pol, GTP syn

-block mRNA capping

 

uses: influenza A&B

-respiratory syncytial virus

-viral hep

 

-hemolytic anemia

-decr. resistance

Term
Acyclovir
Definition

IV, topical, PO; glomerular filtered, some metabolism

 

Nucleoside analogue

-inhib viral DNA pol

-terminates elongation

 

uses: HSV 1 & 2

-mucocutaneous infections (immunocompromised)

-varicella-zoster

 

-resistant strains

Term
Trifluridine
Definition

topical

 

nucleoside analogue

 

uses: herpes keratitis

-topical 


Term
Vidarabine
Definition

large dose PO

 

nucleoside analogue

 

uses: neonatal herpes

-large, oral doses

Term

ganciclovir

(acyclovir + CH2OH)

 

Definition

-IV (acute), oral (maintainance)

 

nucleoside analogue

 

uses: CMV @ kidney transplant pt

-bone marrow suppression

-CNS effects

Term
Cidofovir
Definition

IV

 

nucleoside analogue

 

uses: CMV retinitis @ ganciclovir resistant

-IV

 

-bone marrow, renal toxicity

Term
Foscarnet
Definition

IV

 

pyrophosphate analogue

 

uses: CMV retinitis @ ganciclovir resistance 

-also works agianst Herpes and HIV

-more expensive but better tolerated

 

-decr. renal function

Term
Interferons
Definition

IM, subQ, topical

 

glycoproteins

 

uses: chronic Hep B & C

-genital warts

-herpes zoster

-given with ribavirin

 

causes neutropenia -> flu like symptoms

Supporting users have an ad free experience!