Term
|
Definition
| antiviral- neuramindase inhibitor. oral. effective against A&B. for subtype H3N2, influenza B or H1N1if <7rs, or asthma/COPD |
|
|
Term
|
Definition
| antiviral- neuramindase inhibitor. inhaled. effective against A&B. For subtype unknown or H1N1 |
|
|
Term
|
Definition
| antiviral- uncoating inhibitors, inhibits release of new virons. oral, only RNA viruses, influenza A. |
|
|
Term
|
Definition
| antiviral- uncoating inhibitors, inhibits release of new virons. oral, only RNA viruses, influenza A. |
|
|
Term
|
Definition
| Antiviral- synthetic guanosine analog. Inhibition of viral mRNA synthesis. effective against broad RNA & DNA. TX for severe Respiratory syncytial virus (RSV) in infants and young children; acute hep A, influenza A&B, lassa hemorrhagic fever |
|
|
Term
|
Definition
| antiviral- hepatitis virus, appears to induce host cell enzymes that inhibit viral RNA translation & ultimately lead to degradation of viral mRNA & tRNA. AE fever, lethargy, bone marrow depression, cardiovascular problems. |
|
|
Term
| Rebetron (INFa2b+ ribavirin) |
|
Definition
| antiviral- TX of chronic Hep C |
|
|
Term
|
Definition
| antiviral- herpes. guanosine analog. selectively inhibits viral DNA polymerase & is incorporated into viral DNA where it acts as a chain terminator. distributes everywhere. TX for genital/oral herpes. DOC herpes simplex encephalitis. Not CMV |
|
|
Term
|
Definition
| antiviral- herpes. analog, inhibits viral DNA polymerase. TX for cytomegalovirus (CMV) |
|
|
Term
|
Definition
| antiviral- herpes. shingles vaccine |
|
|
Term
|
Definition
| antiviral- herpes. IV, broad antiviral activity; reversibly inhibits DNA//RNA polymerases. TX CMV, HSV, HZV |
|
|
Term
|
Definition
| antivirals- herpes. inhibit DNA polymerase. TX HSV 1, HSV 2, HZV |
|
|
Term
| Enfuvirtide (T20, ENF, Fuzeon) |
|
Definition
| antiviral-HIV, viral fusion inhibitor, viral GP41- entry inhibitor. AE= rxn at injection site, eosiniphilia, systemic hypersensitivity rxn, ↑ bacterial pneumonia |
|
|
Term
|
Definition
| antiviral- HIV, integrase inhibitor, inhibits integration of viral strand DNA into host DNA. AE= nausea, HA, Diarrhea |
|
|
Term
|
Definition
| antiviral- HIV, NRTI. azt incorporated into the growing viral DNA- causes chain termination. well absorbed PO, penetrate CNS. decreases transmission of HIV to fetus |
|
|
Term
| BMS, HA, NV, anorexia inhibition mitochondria DNA polumerase, peripheral neuropathy, pancreatitis, lipoatrophy, liver toxicity |
|
Definition
|
|
Term
| Didanosine (ddl), Zalcitabine (ddC) |
|
Definition
| antivirals- HIV, NRTI's. terminates DNA chain elpngation |
|
|
Term
|
Definition
| antiviral-HIV, NNRTI's. prevent chain elongation, lack effect on blood forming elements |
|
|
Term
|
Definition
| antiviral-HIV, protease inhibitors. prevents post-translational processing of viral polyproteins,well tolerated. oral, p450 metabolism. given in combination |
|
|
Term
|
Definition
| antiviral- HIV, protease inhibitors |
|
|
