Term
|
Definition
guanine analog, need thymidine kinase to activate
used for herpes, not EBV or CMV because no thymidine kinase
-renal toxicity |
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Term
|
Definition
(or valganciclover)- acyclovir anolog->used for CMV
-killed nuetrophils and platelets |
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Term
|
Definition
DNA poly and reverse transciptase inhibitor
-AIDs with acyclovir resistant |
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Term
|
Definition
cytosine analog-herpes and pox
-acyclovir backup |
|
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Term
|
Definition
highly active antiretroviral treatment
-2 NRTIs and 1 protesse inhibitor or NNRTI |
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Term
|
Definition
nucleotide reverse transcriptase inhibitor- NUKE
-zidovudine, lamivudine, didanosine, zalcitabine, stavudine, tenofovir, abacavir, tenofovir
-didanosine, zalcitabine, stavudine-->peripheral neuropathy (DZS)
-zidovudine (AZT)-decreases neutrophils and platelets, contrindicated with ganciclovir |
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Term
|
Definition
|
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Term
|
Definition
|
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Term
|
Definition
| NRTI, peripheral neuropathy |
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|
Term
|
Definition
| NRTI, peripheral neuropathy |
|
|
Term
|
Definition
| NRTI, peripheral neuropathy |
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Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| non-nucleotide RT inhibitors |
|
Definition
-NNRTI- bind directly and noncompetitively to RT
-cross resistance
-elevate liver enzymes
-nevirapine, delvirdine, efavirenze |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
|
Definition
PI- stop the cleavage of large polypeptide
-metabolic abnormalities- dyslipidemia, insulin resisistance, lipodystrophy
-buffulo hump
"navir" |
|
|
Term
|
Definition
| "navir"=protease inhibitor |
|
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Term
|
Definition
| -fusion inhibitor-last ditch effort |
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Term
|
Definition
| inhibits viral genome uncoating-influenza A an antiparkinson |
|
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Term
|
Definition
inhibits viral genome uncoating-influenza A and anti-parkinson
-safer than amantadine w/ no CNS penetration |
|
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Term
|
Definition
| neuramidase inhibitor- oral tablet- flu A |
|
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Term
|
Definition
| neuramidase inhibitor-nasal/oral spray-flu A |
|
|
Term
|
Definition
broad spectrum-teratagenic
-severe RSV, lassa fever, Hanta
-Hep. C with INFs |
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