Term
|
Definition
Tx: mainly HSV
Ax: Activated (P) by Tyrosine Kinase (TK)
Chain Terminator (no 3'-OH)
SE: Nephrotoxicity
Ms: Wide Distribution - CSF: 50% of Serum Con.
|
|
|
Term
|
Definition
Tx: CMV
Ax: TK Activated
Inhibits viral DNA Poly
SE: Nephrotoxicity
Ms: Intravitreal (eye drops) |
|
|
Term
|
Definition
Tx: use with Acyclovir or Ganciclovir failure
**no TK activated
Ax: inorganic pyrophosphate analog
Directly inhibits viral DNA (CMV), RNA poly, and HIV RT
SE: Nephrotoxicity, Hypocalcemia --CNS effects
IV only
|
|
|
Term
|
Definition
Tx: Influenza A (prophylaxis + Tx)
Ax: Inhibits Viral M2 H+ Channel
inhibits viral uncoating
Distribution - penetrated nasal and lung secretions
SE: CNS Effects - Ataxia, Insomnia, Seizures
> 90% excreted in Urine |
|
|
Term
|
Definition
Tx: Influenza A & B (w/in 48hrs)
Ax: Sialic Acid Analog→inhibits neuraminidase (NA)
NA needed for viral release from host cell
SE: mild GI effects, abnormal behaviors (FDA), watch children for abnormal behaviors
Mc: Oral absorb. rapid |
|
|
Term
|
Definition
Tx: Chronic Hepatitis C, RSV (in kids)
Ax: not fully understood
inhibits IMPDH → dec. guanosine
Interferes with mRNA capping & RNA Poly
SE: Hemolytic Anemia
Teratogen - req. 6 month washout period after extended use (t1/2=40days) |
|
|
Term
|
Definition
Tx: HIV Suppression (inc. CD4 count)
dec. risk of maternal→fetal transmission
Ax: Nucleoside/nucleotide RT inhibitor (NRTI) must be P by host enzymes for activation
SE: Granulocytopenia → Anemia
Metabolic Acidosis → mito. damage
Hepatotoxicity → Diarrhea |
|
|
Term
|
Definition
Tx: HIV combo Tx only, dec. viral load and inc. CD4
Ax: NNRTI Non-nucleoside RT inhibitor (non-competitive)
SE: Allergic rash + fatal rxns (granulocytopenia, esp. in kids)
Mc: Inc. metabolism of Protease Inhibitors (PIs) |
|
|
Term
|
Definition
Tx: HIV combo Tx only, ↓viral load and ↑CD4
Ax: Protease Inhibitor (PI)
Prevents viral maturation
SE: N/V, Diarrhea, GI pain
Buffalo hump → Trunk obesity
Kidney Stones (4%)
Met: Liver CYP3A4 |
|
|
