Term
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Definition
For Orthomyxovirus, Influenza A and B
Action : Neuraminidase Inhibitor, Sialic Acid Substrate TS Analog
Pharmacokinetics - Taken orally, hydrolyzed to active form in liver, eliminated in urine
Adverse Efx- GI discomfort, nausea
Resistance - Common resistance, but new strains of virus infect each season. |
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Term
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Definition
For Orthomyxovirus, Influenza A and B
Action : Neuraminidase Inhibitor, blocks virus from leaving infected cell.
Pharmacokinetics : Intranasal or inhaled, eliminated in urine
Adverse Efx: Bronchospasm
Resistance : Rare |
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Term
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Definition
For Influenza A Only
Action : Block membrance matrix protein M2
Pharmacokinetics : Oral, eliminated in urine (unchanged), crosses BBB to CNS
Adverse Efx : CNS related, insomnai, dizziness, ataxia, embryotoxic (pregnancy)
Resistance : M2 protein mutation |
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Term
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Definition
For Influenza A
Action : M2 channel blocker, inhibits endosome fusion
Pharmacokinetics : Oral, Unlike Amantadine, metabolized by liver and does not cross BBB to CNS
Adverse Efx : Less than Amantadine, Embryotoxic (Pregnancy)
Resistance : mutation in M2 protein |
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