Term
| What are 5 drugs used for treating herpes virus? |
|
Definition
- acyclovir
- valacyclovir
- famciclovir
- penciclovir
- foscarnet
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Term
| What are 4 drugs used for treating CMV? |
|
Definition
- ganciclovir
- valganciclovir
- cidofovir
- foscarnet
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Term
What are the nucleoside reverse transcriptase inhibitors (NRTIs)?
- name 5 total |
|
Definition
- lamivudine
- zidovudine
- emtricitabine
- abacavir
- tenofovir
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Term
| What is the only nucleotide reverse transcriptase inhibitor? |
|
Definition
| tenofovir, an analog of adenosine |
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Term
| What are two main non-nucleotide reverse transcriptase inhibitors (NNRTIs)? |
|
Definition
- efavirenz
- etravirine (new)
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Term
What are the protease inhibitors?
- name 4 total |
|
Definition
- tipranavir
- lopinavir
- ritonavir *most potent booster
- atazanavir sulfate
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Term
| What is a fusion inhibitor and how is it administered? |
|
Definition
| Enfuvirtide via subcutaneous injection |
|
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Term
| What is an entry inhibitor? |
|
Definition
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Term
| What is an integrase inhibitor? |
|
Definition
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Term
| What are drugs used for Hepatitis B that suppress viral replication? Which two of these are also used for treating HIV? |
|
Definition
- Entecavir
- Tenofovir*
- Lamivudine*
- Adefovir
- Telbivudine
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Term
| What are pegylated interferons and how are they used for treatment of hepatitis? |
|
Definition
A polyethylene glycol moiety attached to interferon decreases clearance and increases half-life so less frequent dosing is necessary;
=> use in combination therapy with oral ribavirin for chronic HCV
--> dosing based on type of interferon and patient weight |
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Term
| What are some adverse effects of pegylated interferons? |
|
Definition
- flu-like symptoms
- thrombocytopenia; granulocytopenia
- increases in aminotransferases
- neuropsychiatric symptoms:
- depression
- anxiety
- agitation
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Term
| What are two old anti-influenza agents and what do they target? |
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Definition
amantadine and rimantadine
inhibit uncoating of viral RNA of seasonal influenza A by targeting M2 protein; prevent replication
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Term
| What are two new anti-influenza agents and what do they target? |
|
Definition
zanamivir and oseltamivir (Tamiflu)
neuraminadase inhibitors that prevent the release of viral progeny from infected cells
* used for both influenza A and B, though there was significant resistance to oseltamivir for seasonal Influenza A in 2008-2009 |
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