Term
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Definition
| isoniazid is a prodrug, activated by catalase binds to an acyl carrier protein blocking mycolic acid synthesis |
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Term
| isoniazid-what is the gene that codes for catalase and what is the gene that codes for the acyl carrier protein? |
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Definition
| catalase-katG acyl carrier protein-inhA gene |
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Term
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Definition
high level resistance-deletions in Kat gene
low level resistance mutation in inhA gene |
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Term
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Definition
| Hepatitis(seen more in old people), Peripheral neuritis, Hemolysis in G6PD, Sideroblastic anemia, SLE in slow acetylators, general inhibitor of p450 |
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Term
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Definition
| inhibits DNA dependent RNA polymerase |
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Term
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Definition
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Term
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Definition
| hepatitis, red-orange metabolites which appear in urine, induction of p450 |
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Term
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Definition
| inhibit synthesis of arabingalactan |
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Term
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Definition
| dose dependent retrobulbar neuritis leading to decreased visual acuity and red-green discrimination defects |
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Term
| pyrazinemide-mechanism, some thing special |
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Definition
| unknown, metabolically activated by bacteria-strains lacking develop resistance |
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Term
| pyrizinemide-side effects |
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Definition
| hepatitis, polyatralgia, myalgia, rash, phototoxicity, hyperuricemia, increased porphyrin synthesis |
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Term
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Definition
| nephrotoxicity, ototoxicity, teratogenicity, neuromuscular blockade with decreased release of Ach |
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