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Anti- TB Therapy
Exam 6 Material
14
Medical
Graduate
12/06/2010

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Cards

Term
What are the five first-line anti-TB drugs?
Definition
Rifampin, Ethambutol, Streptomycin, Pyrozinamide, and Isoniazid
Term
What must be given in conjunction with isoniazid?
Definition
pyridoxine (Vit. B6)
Term
What are the three major toxicities associated with isoniazid?
Definition
Hepatotoxicity, Neurotoxicity (Reduce with pyridoxine), and CNS toxicity
Term
What toxicity associated with rifampin is considered to be "uncommon" but still is told to the patient?
Definition
thrombocytopenia
Term
What is considered the most important side-effect of rifampin?
Definition
It causes drug interactions.
Term
For individuals taking pyrazinamide, besides the hepatotoxicity, what other adverse effect could they have possibly?
Definition
elevated uric acid concentrations
Term
When taking ethambutol, how does the dosing get set?
Definition
It's adjusted according to the degree of renal insufficiency in the patient- also to ensure that ocular toxicity is avoided
Term
In a 6 month plan for treating TB, what three drugs must be taken together each day for at least 8 weeks?
Definition
Rifampin, Isoniazid, and Pyrazinamide
Term
What are the three major second-line agents that we must pay attention to ?
Definition
the quinolone class, amikacin, and capreomycin
Term
For MDR-TB or suspicion of MDR-TB, what's the recommended treatment regimen?
Definition
5-6 or more drugs initially and then accordingly adjust once susceptibilities are known
Term
What type of TB is not common in HIV patients?
Definition
cavitary TB
Term
What the criteria for airborne isolation?
Definition
abnormal CXR and any suspicion of active TB in the patient
Term
Which one of the first-line TB drugs is NOT hepatotoxic?
Definition
ethambutol
Term
Is ethambutol bacteriostatic or bactericidal?
Definition
bacteriostatic
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