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Antiseizure agents
Thomas lecture
22
Pharmacology
Graduate
09/09/2010
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Term
Acetazolamide
 Definition
Inhibits carbonic anhydrase- acidosis effect?
Term
Carbamazepine (iminostilbene)
 Definition
Na+
Term
Clonazepam (Benzo)
 Definition
GABA: potentiates inhibition through GABA-A receptors
Term
Clorazepate (Benzo)
 Definition
GABA: potentiates inhibition through GABA-A receptor
Term
Diazepam (Benzo)
 Definition
GABA-A
Term
Ethosuximide
 Definition
Ca2+
Term
Felbamate
 Definition
GABA and may also inhibit NMDA receptor currents
Term
Gabapentin
 Definition
GABA by promoting its release, maybe Ca2+
Term
Lacosamide
 Definition
Na+, inhibits NMDA-evoked response and CRIMP-2?
Term
Lamotrigine
 Definition
Na+, may also affect glutamate release
Term
Levetiracetam
 Definition
Unknown; SV2A?
Term
Lorazepam (Benzo)
 Definition
GABA-A
Term
Oxcarbazepine (iminostilbene)
 Definition
Na+ , prodrug
Term
Phenobarbital
 Definition
GABA-A
Term
Phenytoin
 Definition
Na+
Term
Pregabalin
 Definition
Maybe Ca2+
Term
Rufinamide
 Definition
Na+ ?
Term
Tiagabine
 Definition
GAT-1; reduce uptake
Term
Topiramate
 Definition
Na+
Term
Valproate
 Definition
Na+, GABA, and Ca2+
Term
Vigabatrin
 Definition
GABA
Term
Zonisamide
 Definition
Na+ and Ca2+
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