Term
| How to remember these drugs |
|
Definition
| They are haloperidol + -azines |
|
|
Term
|
Definition
| All atypicals blcok Dopamine D2 receptors --> Increased [cAMP] |
|
|
Term
|
Definition
1. Haloperidol
2. Trifluoperazine
3. Fluphenazine
These have more neurologic ADRs and less anticholinergic ADRs |
|
|
Term
|
Definition
1. Thioridazine
2. Chlorpromazine
These have fewer neurologic ADRs and more anti-ACh ADRs |
|
|
Term
|
Definition
| EPS - extrapyramidal - Dystonias, akinesias, akathisias and Tardive Dyskinesia |
|
|
Term
|
Definition
Basically all from an excess of muscle contraction:
Rigidity, myoglobinuria, hyperpyrxia
Rx: Dantrolene and DA agonists like bromocriptine |
|
|
Term
|
Definition
Low potency
Key ADR= Corneal deposits |
|
|
Term
|
Definition
Low potency
ADR: reTinal deposits |
|
|
Term
| Side-effects from blocking other receptors |
|
Definition
1. Anti-Muscarinic - dry mouth, constipation
2. Anti-Alpha adrenergic - hypotension
3. Anti-Histamine - Sedation |
|
|
