Term
|
Definition
| Loss of contact with reality - hallucinations and delusions |
|
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Term
|
Definition
| 1 month of 2 or more of: delusions, hallucinations, disorganized speech, grossly disorganized/catatonic behavior, negative symptoms (affective flattening/alogia/avolition) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Stimulates adenylyl cyclase and increases cyclic AMP |
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|
Term
|
Definition
| Inhibits adenylyl cyclase and decreases cAMP; D2 is classic antipsychotic target; localized in the caudate, putamen and nucleus accumbens; in pituitary DA blockage leads to prolactin secretio; chemoreceptor antiemetic triggering |
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Term
|
Definition
| Example: chlorpromazine; Low potency, anti-cholinergic and histamine problems, orthostasis, alpha blockade |
|
|
Term
|
Definition
|
|
Term
| Risperidone, palliperidone, ziprasidone, olanzapine, clozapine, quietapine, ariprprazole |
|
Definition
|
|
Term
| Mechanism of Atypical antipsychotics |
|
Definition
| 5HT2a blockade, variable D2 potency |
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|
Term
|
Definition
| Partial D2 agonist and 5HT1a but blocks 5HT2a |
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|
Term
|
Definition
| Can cause seizures, neutropenia and agranulocytosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Bradykinesia, tremor, dystonia |
|
|
Term
|
Definition
| low potency typicals, quietapine, clozapine, olanzapine |
|
|
Term
|
Definition
| Quietapine, clozapine, low potency typicals |
|
|
Term
| Toxicity of antipsychotics |
|
Definition
| Tardive dyskinesia and neuroleptic malignant syndrome |
|
|
Term
| Neuroleptic malignant syndrome |
|
Definition
| Acute; muscle rigidity, fever, leukocytosis, AMS, myoglobinemia - treat with dantrolene and bromocriptine or ECT |
|
|
Term
|
Definition
| Metabolic syndrome (olanzapine), cardiotoxicity (wide complex tachyarrythmias = Torsades de Pointes, ziprasidone and thioridazine); Seizure (all lower threshold!); hematologic (agranulocytosis - need a CBC!) |
|
|
Term
|
Definition
| Browning of the lens - thioridizine |
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|
