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Details

Antiprotozoal (sporozoal) + malarial
b4+
26
Medical
Graduate
07/22/2012

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Cards

Term
best treatment of Toxoplasmosis
Definition
Sulfadiazine
Term
Pyrimethamine and sulfonamide
Definition
Sulfadiazine
Term
May want to administer Leucovorin with this to protect against folate deficiency
Definition
Sulfadiazine
Term
synthetic hydroxy-naphthoquinone.
Highly lipophilic.
Resembles ubiquinone.
Inhibits mitochondrial ETC and related processes
Definition
Atovaquone (Mepron)
Term
Used in toxoplasmosis and AIDS patients to treat P. carinii pneumonia.

Alternate drugs: Spiramycin, Clindamycin
Definition
Atovaquone (Mepron)
Term
Antimycobacterial drug, but also used for fungal/protozoal pneumocystosis
Definition
Dapsone
Term
Eflornithine IV used to treat
Definition
Pneumocystosis
Term
Unknown mechanism possibly polymerase or oxidative phosphorylation?
Parenteral administration for PCP
Renally cleared
half life varies
Definition
Pentamidine
Term
probably number one treatment for PCP
Definition
TMP-SMZ
Term
slow acting for eythrocytic cycle:
Definition
Proguanil and pyrimethamine (inhibits plasmodial DHFR)
Term
Exoerythrocytic stage DOC
Definition
Chloroguanide (Proguanil)
Term
Tissue schizonticides - prevent relapse:

mechanism: latent exo-erythrocytic form
Drug
Definition
Primaquine
Term
Gametocides - prevents infection in mosquito

destroys gametocytes in human blood and prevents vector transmission
DOC for P. falciparium
Definition
Primaquinine
Term
Gametocides - prevents infection in mosquito

destroys gametocytes in human blood and prevents vector transmission
DOC for species besides falciparium
Definition
Chloroquine, Quinine
Term
Possibly inhibits plasmodial heme polymerase? Intercalation w/ parasitic dna
Definition
Chloroquine
Term
Proper concentrations safe drug.
High dose = rare:
retinal damage
ototoxicity
visual disturbances
Definition
Chloroquine
Term
Used for chloroquine resistant plasmodium inections (P. Falci)
Damages parasite membranes
CDC limits use
Definition
Mefloquine
Term
Its oxidants are schizonticides that inhibit plasmodial DNA replication
Definition
Primaquine
Term
Only drug used clinically to eradicate latent tissue and hepatic forms responsible for relapses (vivax, ovale)
Definition
Primaquine
Term
Reserve drug. For resistant strains.

Useful in asexual erythrocytic forms , not active vs. exoerythrocytic forms
Definition
Quinine
Term
blood schizonticide(erythrocytic) for chloroquine resistant Falciparium
Definition
Quinine
Term
Inhibits DHFR. Use with chloroquine in prophalaxis
Definition
Proguanil
Term
Available in US only in combo with Atovaquone for malaria
Definition
Proguanil
Term
Combo of Atovaquone and Proguanil
Definition
Malarone
Term
Considered best drug for Malaria
Definition
Malarone
Term
administered orally as tablet and should be with food or milk
Definition
Malarone
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