Term
| 2 main drugs to kill Trypanosoma gambiense |
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Definition
| Melarsoprol, Eflornithine |
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Term
| Main drug to treat Trypanosoma cruzi |
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Definition
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Term
| Polysulfonated naphthyl urea. inhibits several parasytic enzymes, exact mechanism unknown |
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Definition
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Term
| DNA and RNA polymerase inhibition? Oxidative phosphorylation inhibitor? |
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Definition
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Term
| Trivalent arsenical that binds to and inhibits parasitic enzymes. Especially SULFHYDRYL groups (more sensitive to parasitic enzymes than the host). |
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Definition
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Term
| Used in later stages of CNS involvement. Given IV 70% appers in feces due to rapid excretion |
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Definition
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Term
| Trivalent arsenical binds to parasytic enzymes |
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Definition
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Term
Parenteral formulation available from WHO.
Inhibits polyamine biosynthesis in Trypanosoma.
Inhibitor of ornithine decarboxylase is effective and greatest hope for late stage trypanosomiasis. |
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Definition
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Term
| Eliminated by kidneys. Wide range of hematological adverse effects. Topical formulation available for reducing unwanted facial hair in women (Vaniqa) |
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Definition
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Term
| Vaniqa : topical formulation for reducing unwanted facial hair in women |
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Definition
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Term
| suppressive and possibly curative. *Produces intracellular free radicals that kill organism* |
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Definition
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Term
Used at chronic stages of disease (trypanosoma) with minimal effects.
oral administratoin w/ biotransformation and metabolites excreted by kidneys. |
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Definition
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Term
| binds to proteins and DNA (electron acceptor) of flagellate |
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Definition
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Term
amebicidal, bactericidal, trichomonacidal. Disrupts DNAs tertiary structure and inhibits nucleic acid synthesis.
Anaerobic organisms and cells |
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Definition
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Term
| Binds to membrane phospholipids of flagellate. Crosses placenta. |
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Definition
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Term
| Oral synthetic antiprotozoal agent for treatment of cryptosporidosis or giardiasis |
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Definition
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Term
| Treatment strategy for Giardia uses |
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Definition
| Metrondiazole and Tinidazole |
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Term
| Causes disulfram like reaction, if you drink alcohol you will throw up!! |
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Definition
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Term
| Less disulfram like reaction disrupts DNA tertiary structure inhibiting DNA synthesis . Very effective vs. anaerobic organisms |
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Definition
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Term
| Treatment for trichomoniasis |
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Definition
| Metronidazole and Tinidazole |
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