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antiprotozoal drugs
pharm ch. 53
26
Pharmacology
Graduate
10/30/2009

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Term
MOA of chloroquine
Definition
prevents polymerization of heme
Term
chloroquine is DOC for
Definition
acute attacks of p falciparum and nonfalciparum malaria
Term
MOA of quinine
Definition
blocks DNA replication by binding to DNA
Term
clinical use of quinine
Definition
chloroquine resistant falciparum
Term
toxicity of quinine
Definition
cinchonism -GI distress, headache, vertigo, blurred vision, tinnitus
Term
MOA primaquine
Definition
cellular oxide
Term
clinical use of primaquine
Definition
liver stage of vivax and ovale
Term
MOA of sulfonamides
Definition
blocks folic acid synthesis
Term
clinical use of sulfonamide
Definition
falciparum
Term
drugs for amebiasis
Definition
diloxanide, iodoquinol, paromomycin
Term
which statement about antiprotozoal drugs is accurate
Definition
a combination of primaquine and clindamycin is an alternative drug regimen for PCP
Term
which antimalarial drug causes a dose-dependent toxic state that includes flushed and sweaty skin, dizziness, nausea, diarrhea, tinnitus, blurred vision, and impaired hearing
Definition
quinine
Term
plasmodial resistance to chloroquine is due to
Definition
decreased accumulation of the drug in the food vacuole
Term
prophylaxis for chloroquine-resistant falciparum is
Definition
mefloquine
Term
which drug should be used for oral tx of acute attack of vivax
Definition
chloroquine
Term
which drug should be given later to eradicate schizonts and latent hypnozoites in the patient's liver
Definition
primaquine
Term
preferred tx that he should have received for initial symptoms of e histolytica
Definition
metronidazole plus diloxanide furoate
Term
the drug regimen most likely to be effective in treating severe extraintestinal disease in this patient is
Definition
metronidazole plus diloxanide furoate
Term
this drug is the antimalarial agent most commonly associated w/ causing an acute hemolytic rxn in pts w/ G6PD deficiency
Definition
primaquine
Term
drinking water w/o purification tx w/
Definition
metronidazole
Term
this drug can clear trypanosomes from the blood and lymph nodes and is active in the late CNS stages of african sleeping sickness
Definition
melarsoprol
Term
metronidazole is not effective in the tx of
Definition
pneumocystosis
Term
which drug is recommended as the DOC for oral tx of uncomplicated malaria caused by chloroquine-resistant falciparum
Definition
quinine
Term
side effect of chloroquine
Definition
hemolysis in G6PD deficiency, bullseye retina
Term
side effect of metronidazole
Definition
seizures, ataxia, dizziness, disulfiram-like rxn
Term
side effect of primaquine
Definition
hemolysis in pts w/ G6PD deficiency
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