Term
| differntial uptake of toxic compounds |
|
Definition
|
|
Term
|
Definition
| protozoal GI tract infections such as Entamoeba and Giardia |
|
|
Term
|
Definition
no absorbed into human system, stays in GI tract
inhibits protein synthesis by causing tRNA dissociation |
|
|
Term
| tetrahydrofolic acid synthesis inhibitors |
|
Definition
pyrimethamine and sulfonamides
proguanil (andatovaquone) |
|
|
Term
| anaerobic metabolism of pyruvate inhibitor |
|
Definition
|
|
Term
|
Definition
with sulfadoxine
treating chloroquine-resistant malaria |
|
|
Term
|
Definition
| inhibits THFA synthesis by inhibiting enzymes |
|
|
Term
|
Definition
| in combo to treat chloroquine resistant malaria |
|
|
Term
|
Definition
| inhibit THFA synthesis by stopping enzymes |
|
|
Term
|
Definition
with atovaquone
treatment of malaria |
|
|
Term
|
Definition
|
|
Term
|
Definition
anaerobic bacteria
microaerophillic bacteria and protozoa |
|
|
Term
|
Definition
inhibits pyruvate metabolism process
damages DNA |
|
|
Term
| normal hemoglobin metabolism |
|
Definition
food vacuoles degrade hemoglobin to energy source and toxic heme
converts heme to nontoxic hemozoin |
|
|
Term
|
Definition
| prophylaxis and treatment of malaria |
|
|
Term
|
Definition
inhibits heme-->hemozoin
free heme becomes toxic to plasmodium cells |
|
|
Term
|
Definition
very common
switch between chloroquine and other drugs every 5-10 years |
|
|
Term
| quinine and mefloquine use |
|
Definition
treatment of chloroquine resistant malaria
combo with other drugs |
|
|
Term
| quinine and mefloquine moa |
|
Definition
| inhibition of hemozoin formation similar to chloroquine |
|
|
Term
|
Definition
|
|
Term
|
Definition
| treatment and prevention of pneumocystis jirovecii pneumonia (pcp) |
|
|
Term
|
Definition
| binds to protozoal NADH dehydrogenase complex and inhibits electron transport |
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|
