Term
| Aminoquinoline antimalrials |
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Definition
| Primaquine, CHloroquine, Amodiaquine, Mefloquine, Quinine, Quinidine |
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Term
| useful for all plasmodial infections; toxicity: hemolytic anemia |
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Definition
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|
Term
| toxicities: cinchonism = tinnitus, headache, blurred vision, N/V; hypoglycemia, arrhythmias, hypotension |
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Definition
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|
Term
| highly toxic in overdose; widespread resistance-- cannot use it for falciparum |
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Definition
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|
Term
| toxicities: neuropsychiatric reactions (psychosis, convulsions) |
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Definition
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|
Term
| rapid resistance to either one alone (only used in combo) |
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Definition
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|
Term
| Rapid blood schizonticide, inhibitis cytochrome b in electron transport chain, synergistic combination with proguanil |
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Definition
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|
Term
| converted by CYP2C19 to cycloguanil which inhibits plasmodial DHFR |
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Definition
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Term
|
Definition
| tissue schizonticidal activity against P. falciparum only |
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Term
| Reactivity of endoperoxide bridge with heme iron produces oxidative stress in food vacuoles causing toxicity to the parasite |
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Definition
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Term
| Artemisininsalog of trimethoprim but more selective for eukaryotic DHFR; also useful in toxoplasmosis and PCP |
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Definition
| primary activity against erythrocytic P. falciparum but increasingly used in P. vivax infections |
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|
Term
| ALWAYS combine with another long-acting drug |
|
Definition
| artemisinin-containing therapy |
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|
Term
| analog of trimethoprim but more selective for eukaryotic DHFR; also useful in toxoplasmosis and PCP |
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Definition
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|
Term
| slow blood schizonticides (typically reserved for when you have absolute intolerance of more preferred agents |
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Definition
| Tetracycline, doxycycline, clindamycin |
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|
Term
| used for four weeks after exposure to malaria for suppressive care |
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Definition
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|
Term
|
Definition
| P. falciparum and P. malariae only |
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|
Term
| Blood schizonticides + primaquine for radical cure of: |
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Definition
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|
Term
| malaria chemosuppression: DOC except for P. falciparum |
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Definition
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|
Term
| marlia chemosuppression: for chlorquine-resistant P. falciparum malaria |
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Definition
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|
Term
| used for multidrug resistant malaria (disadvantage has a slow onset but resistance is low) |
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Definition
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