Term
Metronidazole ( Flagyl).
mechanism of action? |
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Definition
| antibacterial/ antiparasitic. It has a nitro group and that nitro group generates reactive oxygen , which causes destrutive effects to the cell components such as the DNA, proteins, membranes of the micro-organism. |
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Term
| Why is Metronidazole( flagyl) considered a prodrug? |
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Definition
| because it has to be activated by the bioreducation of the 5-position nitro group |
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Term
| are the organisms aerobic or anaerobic that are effected by the antibacterial/antiparastic drug metronidazole (flagyl) |
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Definition
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Term
| what is Metronidazole (flagyl) used for the treatment of? |
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Definition
| protozoa infections amebiasis ( inestinal and extraintestinal), giardiasis, and trichomoniasis, gram positive bacilli clostridium difficile, helibacter pylori infection |
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Term
| Metronidazole ( Flagyl). treatment?? |
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Definition
| protozoa infections amebiasis ( inestinal and extraintestinal), giardiasis, and trichomoniasis, gram positive bacilli clostridium difficile, helibacter pylori infection |
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Term
| Tindazole (Tindaamax)- mechanism of action? |
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Definition
| the same of metronidazole |
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Term
| Tindazole (Tindamax) is used for the treatment of what? |
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Definition
| amebiasis, giardiasis and trichomoniasis. It also had a nitro group. |
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Term
| Nitazoxanide (Alina) what is its mechanism of action? |
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Definition
| it inhibits pyruvate ferredoxin oxidoreductase enzyme, which is responsible for anerobic glucose energy metabolism |
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Term
| Nitazoxanide (Alina) and its treatment usages? |
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Definition
| diarrhea caused by giardia lamblia. Its also a prodrug |
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Term
| Pentamidine (pentam -300, Nebupent)- mechanism of action? |
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Definition
| it inhibits the topoisomerase ( an enzyme that regulates unwinding or underwinding of DNA) |
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Term
| Atovaquone (Mepron) . mechanism of action? |
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Definition
| interferes with the mitochondrial respiratory chain- especially by inhibiting ubiquinone reductase(it is the first enzyme (complex 1) of the mitochondrial electron transport chain |
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Term
| most severe malaria is caused by? |
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Definition
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Term
| Quinine, mechanism of action? |
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Definition
| a drug used for malaria. blood schizontide ( activily against plasmodium in the erythrocytic stage |
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Term
| in the drugs of malaria, what does the quinine moiety look like? |
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Definition
| it looks like two benzene rings attachted together with a H3CO group on the 6th carbon |
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Term
| Choroquinine ( Aralen) has a Cl at the carbon 7 of the two attached benzene rings, what is that cl atom useful for? |
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Definition
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Term
| How many chiral centers does chloroquine have? |
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Definition
| one chiral center, which is right next to the amine group |
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Term
| Mefloquine, what is the struture? how many chiral centers does it have? |
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Definition
| The sturture is the same as all quinines with the two benezens rings attached to each other. but it has two triflouromethyl group |
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Term
| what are the positions on chloroquine that having an alkylation there might reduce the activity? |
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Definition
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