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| normal gene product prevents cell from entering S cycle |
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| Mutations seen in osteosarcoma, Ca *breast, colon, and lung* |
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| Mutations seen in many cancers including leukemias, sarcomas, Ca breast, brain |
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| Role in DNA Repar and about 10% of breast cancers also Ca ovary |
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| Cell regulator gene mutants associated w/ adenomatous polyps of colon and Ca Colon |
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| one of the guardian genes "new guardian" |
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