Term
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Definition
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Term
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Definition
| inhibition of mycolic acids |
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Term
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Definition
| inhibits DNA-dependent RNA polymerase |
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Term
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Definition
| inhibits arabinosyl transferases |
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Term
| the primary reason for use of drug combinations in the tx of TB is to |
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Definition
| delay or prevent the emergence of resistance |
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Term
| course of action for pulmonary TB is |
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Definition
| hospitalize the pt and start tx w/ 4 antimycobacterial drugs |
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Term
| when tx for TB is started, which drug regimen should be initiated in this pt? |
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Definition
| INH, rifampin, pyrazinamide, ethambutol |
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Term
| which statement concerning the possible use of INH in this pt is false |
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Definition
| persons from southeast asia require lower maintenance doses of INH than most other persons in the US |
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Term
| on her release from the hospital, the pt is advised not to rely solely on OC to avoid pregnancy b/c they may be less effetive while she is being maintained on antimycobacterial drugs. the agent most likely to interfere w/ the action of OC is |
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Definition
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Term
| the mechanism of high level INH resistance of M TB is |
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Definition
| reduced expression of the katG gene |
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Term
| a pt w/ AIDS and a CD4 cell count of 100/uL has persistent fever and weight loss associated w/ invasive pulmonary disease that is due to MAC. optimal management of this pt is to |
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Definition
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Term
| a pt w/ pulmonary TB resulting from an INH-susceptible strain of M tuberculosis (rate of INH resistance known to be <4%) has been treated w/ INH, rifampin, and pyrazinamide for a total of 2 mo. if the pyrazinamide is stopped at this time, tx should be continued w/ INH and rifampin for a min of |
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Definition
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Term
| a 10 yo boy has uncomplicated pulmonary TB. after initial hospitalization, he is now being treated at home w/ isoniazid, rifampin, and ethambutol. which statement about this case is accurate? |
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Definition
| his mother, who takes care of him, should receive INH prophylaxis |
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Term
| this drug has been used prophylactically in contacts of children w/ infection caused by H. influ B. it is also prophylactically in meningococcal and stap carrier states. although the drug eliminates a majority of meningococci from carriers, highly resistant strains may be selected out during treament |
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Definition
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Term
| which statement about antitubercular drugs is accurate? |
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Definition
| resistance to ethambutol involves mutations in the emb gene |
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Term
| once weekly administration of which of the following antibiotics has prophylactic activity against bacteremia caused by MAC in AIDS pts? |
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Definition
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Term
| risk factors for multidrug-resistant TB |
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Definition
| hx of tx of TB w/o rifampin, recent immigration from asia and living in an area of over 4% isoniazid resistance, recent immigration from latin america, residence in regions where isoniazid resistance is known to exceed 4% |
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Term
| which drug is most likely to cause loss of equilibrium and auditory damage |
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Definition
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Term
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Definition
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Term
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Definition
| secretions turn red, hepatitis, increasing metabolism of OC |
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Term
| side effects of pyrizinamide |
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Definition
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Term
| side effects of streptomycin |
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Definition
| vestibular toxicity and nephrotoxicity |
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Term
| side effects of capreomycin |
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Definition
| ototoxicity and nephrotoxicity |
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Term
|
Definition
| reversible retrobulbar neuritis |
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Term
| cycloserine (seromycin) side effects |
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Definition
| allergic dermatitis, CNS toxicity |
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