Term
| Imitrex, Maxalt, Axert, Frova, Relpax, Amerge, Zomig |
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Definition
Class: Triptan
MAE: agonize 5ht ab/ad agonists in vasculature in order to vasoconstric, inhibits pain signal, inhibit vasoactive peptides
Drug-drug: MAOIs, CYP3a4s, SSRIs
Fastest:Maxalt
Slowest:Zomig
Lowest reoccuring: Zomig
A/E: Maxalt interacts with propanolol
Metabolized:cyp3a4
Formulas: PO, subq (imitrex) nasal (imitrex zomig)
Contraindication: heart disease, HTN, stroke, preg,
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Term
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Definition
ergotamine/dihydroergotamine
Clinical use: prolonged duration migraines not 1st line of defense
MAE: 5ht 1b/1d agonists
Pharmkinetics: poor bioavail 2-5%
A/E: N/V rebound headaches
C/I: CAD,PVD, HTN,HepaticC/Renal disease
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Term
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Definition
no dependence, no rebound HA
admin: sq IM IV with antiemetic
C/I: elderly, elderly, HTN, heart disease, MAOIs |
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Term
| First-line agents for migraine |
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Definition
NSAIDs :high dose
ASPIRIN:high dose
TYLENOL :high dose
combo-products |
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Term
| mono- or adjunct therapy for migraines |
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Definition
antiemetics- reglan, thorazine, prochlorperazine
benzos opiods barbs: not for chronic
Prevention: beta block, ca channels, TCAs, anticonvulsants, Ergot |
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