Term
| What are vinca alkaloids? |
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Definition
Bind to beta tubulin to block polymerization - M phase. IV, VESICANT
- Vincristine - liposomal, IV, neurotoxic
- Vinblastine - IV
- Vinorelbine |
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Term
| What vinca alkaloid does not have dose limiting myelosuppression? |
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Definition
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Term
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Definition
Bind beta tubulin, promoting polymerization - M phase. IV
- Paclitaxel - IV, in castor oil (hypersensitivity, more sever than polysorbate 80). Pretreat w/ steroid, benadryl, ranitidine.
- Paclitaxel protein bound - no hypersensitivity
- Docetaxel - IV, more severe myelosuppression, milder hypersensitivity/PN
- Cabazitaxel - In Cremophor. Major hypersensitivity.
**Prevention of myelosuppression w/ filgrastim |
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Term
| How does Ixabepilone work? |
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Definition
binds to b-tubulin, promotes the polymerization of microtubules
- IV, in Cremophor. VERY neurotoxic, BAD hypersensitivity |
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Term
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Definition
Binds to b-tubulin, block the polymerization of microtubules
- IV, myelo, PN, cardiotoxic |
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