Term
Penicillins:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity?
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Definition
Cidal
Time
Both (better at anaerobic)
Mostly gram +
GI upset, anaphylaxis
Note: Potentiated better at Gram- |
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Term
| Name 3 "plain" Penicillins and 2 potentiated. |
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Definition
Penicillin
Amoxicillin
Ampicillin
B-lactamase inhib:
Amoxicillin Clavulanate
Ticarcillin Clavulanate |
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Term
Cephalosporins:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
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Definition
Cidal
Time
1st gen aerobic--3rd gen both
1st gen gram + --3rd gen gram-
GI upset and anaphylaxis |
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Term
Name 1st 2nd and 3rd gen cephalosporins.
Name the "new" cephalosporins. |
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Definition
1st: cefadroxil, cefazolin, cephalexin
2nd: cefoxitin, cefaclor
3rd: Cefotaxime, ceftiofur, ceftazidime
"New": Simplicef, Convenia, Cefovecin |
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Term
Aminoglycosides:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal
Concentration
AEROBIC
GRAM -
Ototoxic, nephrotoxic, mms weakness
Note: Inactivated in purulent material. |
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Term
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Definition
Amikacin
Gentamicin
Neomycin
Tobramycin |
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Term
Fluroquinolones:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal
Concentration
AEROBIC
Mostly gram -
Cartilage Degen, retinal degen
Note: Good intracellular activity, good penetration |
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Term
|
Definition
Enrofloxacin
Ciprofloxacin
Orbifloxacin
Mabrofloxacin |
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Term
Sulfonamides:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal
Time
AEROBIC
Both + and -
Dobermans= idosyncratic arthropathy, IMHA, Dry Eye |
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Term
| Name 2 potentiated sulfas: |
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Definition
Trimethoprim-sulfanamide
Ormithoprim-sulfadimethoxine |
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Term
Tetracyclins:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Static
Cidal/static
Mostly aerobic
Both + and -
GI upset, Tooth dicoloration, nephrotoxicity....thermometer, shot glass and pills? Who knows.
Note: Good intracellular activity (RICKETTSIAE) |
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Term
|
Definition
Tetracycline
Doxycycline
Minocycline
BTW tetras have good penetration but microbes develop resistance quickly |
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Term
Macrolides:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Static
Time/concentration
mainly anaerobs (not sure...)
Gram + with some exceptions (pasturella, bordatella, mycoplasma, campylobacter
GI upset (can be used for therapeutic effects)
Note: 1st choice for URT infection |
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Term
|
Definition
Erythromycin
Azithromycin
Clarithromycin
Tylosin |
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Term
Lincosamides:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal/Static
Time/Concentration
ANAEROBIC
GRAM +
GI upset
Note: used for t. gondii. also oral infections... which are anaerobic. |
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Term
|
Definition
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Term
Chloramphenicol:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Static
Time
Both
Gram + and -
lots of toxicities... my hands are tired.
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Term
Carbapenem:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal
Time
Both
Gram + and -
GI, CNS?, some thermometer thing... and a dollar sign.
Note: VERY BROAD SPECTRUM |
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Term
|
Definition
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Term
Metronidazole:
Cidal/Static?
Concentration/Time?
Anaerobic/Aerobic?
Gram +/-?
Toxicity? |
|
Definition
Cidal
Concentration
ANAEROBIC
mainly gram -
Severe neurologic abnormalities + seizures
Note: Is anti-protozoal and anti-inflammatory |
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Term
| What antimicrobials have the best penetration? |
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Definition
Man That Shit Can Flow
Metronidazole Tetracyclines Sulfonamides, Chloramphenicol Fluoroquinlones |
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