Term
| cell wall synthesis inhibs |
|
Definition
b lactams e.g. penicilin/cephalosporin
glycopeptides e.g. vancomycin |
|
|
Term
|
Definition
| bind to PBPs = inhibit cross linking of peptidoglycans |
|
|
Term
|
Definition
| bind to d-alanyl-d-alanine portion of pentapeptide required for peptidoglycan formation = no cross linking |
|
|
Term
| protein synthesis inhibitors |
|
Definition
aminoglycosides
tetracyclines
chloramophenicol
macrolides
linezolid |
|
|
Term
|
Definition
| bind to 30s on ribo = non functioning initiation complexes |
|
|
Term
|
Definition
| binds to 30s ribo = prevent elongation of peptide |
|
|
Term
|
Definition
| binds to 50s ribo =inhibits peptidyl transferase |
|
|
Term
|
Definition
inhibits formation of 50s ribo unit.
interacts with peptidyl transferase = blocks polypeptide exit tunnel = peptide dissociates from ribo during translocation
(ALSO ACTS ON HUMAN 50S RIBO UNIT = TOXICITY) |
|
|
Term
|
Definition
| binds to 23s ribosomal rna of 50s unit = prevents formation of initiation complex |
|
|
Term
| nucleic acid synthesis inhibs |
|
Definition
sulphonamides
trimethoprim
quinolones
rifampacin |
|
|
Term
|
Definition
| blocks synthesis of tetrahydrofolic acid (precursor to adenine, guanine, thymine) |
|
|
Term
|
Definition
| inhibit dihydrofolate reductase = no purines/pyramidines/AAs made |
|
|
Term
|
Definition
inhibits DNA gyrase - for g -ve
inhibits topoisomerase IV - for g +ve (mainly s.aureus and cocc) |
|
|
Term
|
Definition
|
|
