Term
| Antimicrobial Chemotherapy |
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Definition
Use of drugs to combat infectious agents
Antibacterial / Antiviral
Antifungal / Antiparasitic
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Term
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Definition
drug is more toxic to the infecting organism than to the host
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Term
| Antibiotics are based on: |
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Definition
| naturally occuring compounds, synthetic, semi-synthetic. |
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Term
| Minimum Inhibitory Concentration (MIC) |
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Definition
minimum concentration of antibiotic required to inhibit the growth of the test organism.
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Term
| Minimum Bactericidal Concentration (MBC) |
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Definition
- minimum concentration of antibiotic required to kill the test organism.
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Term
| Bacteriostatic vs. Bacteriocidal |
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Definition
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Term
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Definition
| reach a certain concentration, no increase in concentration will make a difference, time of exposure makes the difference. Give multiple times a day. |
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Term
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Definition
| higher the concentration, the more bactericidal. Give once a day. |
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Term
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Definition
Toxic dose(TD)/Effective dose (ED)
-drugs with low TI may require close monitoring to avoid toxicity. EXAMPLE: Aminoglycosides, vancomycin. |
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Term
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Definition
1. No/low toxicity
2. Low ability to cause resistance
3. No hypersensitivities
4. Rapid and extensive distribution
5. Long half life (dose less often)
6. Free of interaction with other drugs
7. Convenient and cheap. |
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Term
| Combination Therapy: primary reason |
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Definition
| to prevent emergence of resistance. Only proven with M. Tuberculosis and S. Aureus (fluoroquinolone/rifampin). |
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