Term
| Prevents cells of invading organisms from using substances essential to the cell's growth & development. |
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Definition
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Term
| Interferes w/ steps involved in protein synthesis so that they can't maintain cells & divide. |
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Definition
| Aminoglycosides, Macrolides |
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Term
| Interfering w/ DNA synthesis in cells, leading to inability to divide |
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Definition
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Term
| After permeability of cell membrane allows components to leak out |
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Definition
| Antibiotics, Antifungals, Antiprotozoa |
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Term
| Children should not take this due to the risk of damage to teeth & bones |
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Definition
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Term
| Children should not take this due to the risk of bone damage. |
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Definition
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Term
| Children should not take this due to the risk of increased circulating bilirubin levels |
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Definition
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Term
- Bacteria adapt to their environment by altering cell wall or enzyme systems to protect themselves from unfavorable conditions.
- Produce an enzyme that deactivates the drug (penicillinase)
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Definition
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Term
| The group most sensitive to antibiotics; usually resp. & soft tissue infections (strep, pneumonia) |
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Definition
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Term
| Most likely seen w/ GU/GI infections (e-coli) |
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Definition
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Term
| A constant therapeutic level is needed to prevent the emergence of resistance during low concentrations. "Peak & Through" provides therapeutic level. |
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Definition
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Term
| Two categories of antibiotics that produce allergic anaphlactic reactions. The reaction usually occurs w/ a subsequent exposure to the drug. Anaphlactic shock can be fatal as it causes the pt to suffocate form obstructive resp arrest. ALWAYS assess for allergies & document. Determine if pt is having a side effect or a allergic reaction. Rashes are common (Amoxicillin). Difficulty breathing, hives, other skin reactions, & ventilatory assistance may be emergency treatments. |
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Definition
| Penicillins & Sulfonamides |
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Term
| A monobactum antibiotic is used in pts allergic to: |
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Definition
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Term
| A blood sample "peak" is drawn 30mins to one hr after administration of an IV dose. The lowest blood concentration would be expected right before a dose is given-so "trough" is drawn 30mins before a dose is due. |
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Definition
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Term
Gentamycin
Therapeutic Level=
Toxic Level= |
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Definition
Therapeutic level: 5-10 mcg
Toxic Level: >12mcg |
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Term
Kanamycin
Therapeutic Level=
Toxic Level=
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Definition
Therapetuic Level: 20-25mcg
Toxic Level: >35mcg |
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Term
Amikacin
Therapeutic Level=
Toxic Level= |
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Definition
Therapeutic Level: 15-25mcg
Toxic Level: >25mcg |
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Term
Vancomycin
Therapeutic Level=
Toxic Level |
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Definition
Therapeutic Level: 5-25mcg
Toxic Level: >26mg/mL |
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Term
| The prototype drug for macrolide classfication of antibiotics. |
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Definition
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Term
| Utilized to treat serious infections when aminoglycosides are ineffective. Can cause cardiac arrest if given rapidly IV. |
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Definition
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Term
| Known to lead to the failure of oral contraceptives w/ breakthru bleeding & unplanned PG. |
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Definition
| Oral antibiotics: Tetracylcine |
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Term
| Leads to serious lung damage as well as GI tract, bones, & meninges. The organism is very slow growing & tx must be cont. for 6months-2yrs. |
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Definition
| Mycobacterium TB infection |
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Term
| The prototype 1st-line drug for tx. It affects the mycolic acid coating of the bacterium. It's administered to household members of recently diagnosed pts. |
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Definition
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Term
Isoniazed is used in combination w/ another anti-Tubercular durg until maximum improvement is seen. Using them in combination helps decrease the emergence of resistant strains & affects the bacteria @ various phases during their long & slow life cycle.
(2-3months) |
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Definition
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Term
| Should not be take place during Isoniazed therapy |
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Definition
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Term
| Body fluids may be stained red-orange; permanent contact lenses may be stained. |
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Definition
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