Term
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Definition
•trade name: Inderal
•therapeutic class: Class II antidysrhythmic; antihypertensive
•therapeutic use: Treatment of cardiac dysrhythmia, hypertension, angina, and migraine headaches, and for prevention of MI.
•pharmacologic class: Beta-adrenergic antagonist (nonselective)
•mechanism of action: Nonselective beta- adrenergic blocker, affecting beta1 receptors in the heart, and beta2 receptors in pulmonary and vascular smooth muscle; reduces heart rate, slows myocardial conduction velocity, and lowers blood pressure. |
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Term
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Definition
•trade name: Tenormin
•therapeutic class: Antianginal; antihypertensive
•therapeutic use: Treatment of heart failure, hypertension, angina, and MI.
•pharmacologic class: Selective beta1-adrenergic blocker
•mechanism of action: Selectively blocks beta1- adrenergic receptors in the heart; slows heart rate and reduces contractility. |
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Term
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Definition
•trade name: Cardura
•therapeutic class: Antihypertensive, treatment of benign prostatic hyperplasia (BPH)
•therapeutic use: To treat hypertension; treatment of BPH
•pharmacologic class: Alpha1-adrenergic blocker
•mechanism of action: Selective for Alpha1-adrenergic receptors, thus causes vasodilation; also cause relaxation of smooth muscle around prostate gland |
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Term
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Definition
•trade name: Adalat
•therapeutic class: Antihypertensive, treatment of angina
•therapeutic use: To treat hypertension and variant or vasospastic angina
•pharmacologic class: Calcium channel blocker
•mechanism of action: Selectively blocks calcium channels in myocardial muscle and vascular smooth muscle |
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Term
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Definition
•trade name: Microzide
•therapeutic class: Antihypertensive, treatment of edema
•therapeutic use: To treat hypertension with edema; also approved to treat heart failure, and nephrotic syndrome
•pharmacologic class: Thiazide diuretic
•mechanism of action: Decreases reabsorption of sodium in the kidney by inhibiting the sodium/chloride cotransporter in the distal tubule of the nephron |
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Term
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Definition
•trade name: Vasotec
•therapeutic class: Antihypertensive, treatment of heart failure
•therapeutic use: To treat hypertension; treatment of heart failure
•pharmacologic class: ACE inhibitor
•mechanism of action: Inhibits conversion of angiotensin I to angiotensin II, a vasoconstrictor, and decreases production of aldosterone, resulting in decreased renal sodium reabsorption |
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Term
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Definition
•trade name: Cozaar
•therapeutic class: Antihypertensive
•therapeutic use: Used alone or in combination therapy for treatment of hypertension; treatment of diabetic nephropathy.
•pharmacologic class: Angiotensin II-receptor blocker (ARB).
•mechanism of action: Selectively blocks angiotensin II receptors; blocks vasoconstriction, and release of aldosterone due to interruption of the renin-angiotensin-aldosterone system. |
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Term
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Definition
•trade name: Apresoline
•therapeutic class: Antihypertensive, treatment of heart failure
•therapeutic use: Treatment of hypertension that is refractory to other antihypertensives
•pharmacologic class: Direct-acting vasodilator
•mechanism of action: Relaxes arterial smooth muscle by inhibiting IP3 production |
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