Term
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Definition
Beta-receptor antagonist
SNS inhibitor
Decreases vascular tone & blood volume via decreased SNS mediated renin release |
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Term
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Definition
Calcium channel blocker
Vasodilator via inhibition of vascular smooth muscle contraction |
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Term
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Definition
Angiotensin converting enzyme inhibitor (ACE)
Renin-angiotensin system inhibitors
Decreases vascular tone & blood volume |
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Term
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Definition
Angiotensin I receptor blockers (ARB)
Renin-angiotensin system inhibitors
Decreases vascular tone & blood volume
Most effective at changing vascular structure |
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Term
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Definition
Carbonic anyhydrase inhibitor
Diuretic via action on sodium reabsorption
Increases bicarbonate excretion primarily in proximal tubule
Also acts in the eye to decrease intraocular pressure
Used in bicarbonate elimination, urinary alkalinization and glaucoma |
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Term
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Definition
Osmotic diuretic
Sugar that is not reabsorbed, thus maintains osmotic strength throughout the nephron
Used to prevent renal failure and decrease intracranial/intraocular pressure |
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Term
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Definition
Loop diuretic via action on sodium reabsorption
Inhibits Na-K-2Cl transporter at thick ascending loop of Henle
Used in edema, hypercalcemia, CHF, and when refractory to thiazides |
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Term
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Definition
Thiazide
Diuretic via action on sodium reabsorption
Inhibits NaCl transporter at distal convoluted tubule
Used in hypertension and CHF |
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Term
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Definition
Aldosterone antagonists
Diuretic via action on sodium reabsorption
Competitive antagonist of aldosterone at distal nephron (collecting tubule)
Used in heart failure and as an anti-hypertensive |
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Term
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Definition
Diuretic
Decreases water retention at the distal tubule and collecting duct |
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Term
Enalapril
Losarton
(Diuretics) |
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Definition
RAS inhibitors
Diuretic via action on sodium reabsorption
Decreases Ang-II mediated proximal tubule Na reabsorption via inhibition of Na/H pump and Na/K ATPase
Alters intrarenal absorption
Acts at the proximal tubule and renal post-glomerular resistance vessels
Used in hypertension, edema, CHF, post-MI, diabetes and renal failure |
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Term
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Definition
Potassium sparing drugs
Diuretic via action on sodium reabsorption
Inhibits electrogenic Na+ reabsorption
Used in prevention of hypokalcemia and as an antihypertensive |
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