Term
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Definition
Drugs to treat hyperlipoproteinemia
Inhibitors of HMG-CoA reductase, the rate-limiting step in cholesterol synthesis
Useful as secondary preventative treatment in those with pre-existing CVD or risk of heart disease
Also improve endothelial function, modulate inflammation, maintain plaque stability & prevent thrombus formation |
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Term
Cholestyramine (Questran)
Colesvelam (Cholestagel, Welchol)
Colestipol (Colestid) |
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Definition
Synthetic polymeric resins used as bile acid sequestrants to treat hyperlipoproteinemia
Resins bind bile acids in the intestine & prevents reabsorption
Decreased bile acid levels induces conversion of cholesterol to bile
Decreases VLDL and LDL, increases HDL
Side effects include severe constipation |
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Term
Bezafibrate (Bezalip)
Ciprofibrate (Modalim)
Gemfibrozil (Lopid)
Fenofibrate (TriCor) |
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Definition
Fibric acid derivatives
Drugs to treat hyperlipoproteinemia
Activate PPARs, transcription factors that modulate carb and fat metabolism and adipose tissue differentiation |
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Term
| Niasin (vitamin B3)/nicotinic acid |
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Definition
Drug to treat hyperlipoproteinemia
Binds a GPCR which causes inhibition of fat breakdown
Reduces the production of triglycerides, VLDL and LDL
Increases HLDL more than other drugs |
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