Shared Flashcard Set

Details

Antihelmith/protazoal drugs
Pharm 2 Exam 1
36
Health Care
Graduate
02/03/2009

Additional Health Care Flashcards

 


 

Cards

Term
MOA of Mebendazole
Definition
prevent uptake of glucose = SLOW DEATH!
Term
difference in dosage of mebendazole for pork roundwork
Definition
repeat dose in 10 days!
Term
absorption of mebendazole
Definition

sm %

Term
AE of Mebendazole
Definition

Abd pain and D (only w/ massive infection)

Term

Interactions/Contraidications Mebendazole

Definition

No PREGO

 

Mebendazole<Albendazole<Thiabendazole

Term
Pyrantel pamoate MOA
Definition
NM blockade->paralysis
Term
Pyrantel dosage based on
Definition
wt
Term
AE pyrantel
Definition
GI, Stomach cramps
Term
Praziquantel MOA
Definition

low dose: paralysis->detachment

 

high dose: change in integument->invasion of host defense!

Term
DOC for tapeworm, schistosomia, fluke
Definition
Praziquantal
Term
AE Praziquantel
Definition
HA, Abd pain, drowsiness
Term
Ivermectin MOA
Definition
distrupts n & m function ->hyperpolarization and paralysis + DEATH
Term
AE Ivermectin
Definition
Mazotti Rxn for onchocerciasis
Term
Ascaris lumbircoides
Definition

giant roundworm

 

tx w/ mebendazole, albendazole, pyrantel

Term
Enterobius vermicularis
Definition

pin worm

 

tx mebendazole, albendazole, pyrantel

Term

Ancylostomiasis & Necatoriasis

Definition

hookworm

 

tx mebendazole, albendazole, pyrantel

Term
Tricuris trichura
Definition

whip worm

 

tx mebendazole

Term
strongyloided stercoralis
Definition

threadworm

 

tx ivermectin

Term
trichinosis
Definition

tx mebendazole, prednisone

Term
taenisis
Definition

pork tapeworm

 

tx praziquantel

Term

Diphyllobothriasis

Definition

fish tape worm

 

tx praziquantel

Term

Schistosomiasis

Definition

blood fluke

 

tx praziquantel

Term
chloroquin doseage
Definition

antiprotozoal

 

tx 1 week before, during and 4 wks after

Term
Primaquin AE
Definition
hemolysis in pts w/ G-6 PD-> screen!
Term
Quinine AE
Definition

mild

  

tinnitus, HA, visual

disturbances, N/D Hemolysis in G6PD

deficient pts Cardiac dysrhythmias

Hypoglycemia Prego X

Term
Metronidazole MOA
Definition

disrupts DNA of ameba, giardia, trichimonas

 

Term
Metronidazole AE
Definition

1. N, HA, Metallic taste

 2. stomatitis, GI, vertigo

Term
Interactions/contraindications mebendazole
Definition

NO PREGO!! (3 days to breast feed)

 

warfarin, phenytoin, disulfuram, and lithium metabolism

 

Not EtOH

Term
Tinidazole uses
Definition
tx. ameba, giardia, trich
Term
which is safer for prego protozoal infection
Definition
tinidazole
Term
Mefloquine is used to tx
Definition
prophylax malaria
Term
AE mefloquine
Definition

GI, CNS (TOXIC)

Term
Mefloquine Dosing
Definition

Same as Chloroquine

 

1 wk before, during, and 4 weeks after

Term
Atovaquone metabolism/absorption
Definition

with fatty mean

 

99% PB

 

Term
AE Atovaquone
Definition
GI, skin probs
Term

Atovaquone dosage

Definition
1-2 DAYS before, during, and 7 DAYS after
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