Shared Flashcard Set

Details

Antigen Recognition
Dr. McBitchin' for Exam II
31
Other
Graduate
12/11/2010

Additional Other Flashcards

 


 

Cards

Term
REVIEW
What cells are involved in the innate immune response?
Definition
Mcrophages
Neutrophils
DC
NK cells
Term
REVIEW
What is the role of complement?
Definition
Opsinization
MAC attack
Term
REVIEW
What cytokines (and functions) are involved in the innate response?
Definition
IL 1
IL 8
IL 12
TNF alpha
Term
REVIEW
What are the effector mechanisms against a) extracellular and b) intracellular pathogens?
Definition
a) complement
b) dendritic then later NK cells
Term
Difference between innate and adaptive immune response?
Definition
Adaptive is driven by antigen-specific receptors
Term
Antigen Specificity
Definition
Describes the properties of antibodies and TCR that interact selectively with only one type or a few types of antigens (epitopes).
Term
Why are B cells flexible?
Definition
Hinges on a disulfide bond
Term
B cell start off as ___ ____ proteins. T cells, however, remain on the ____.
Definition
Cell membrane
membrane
Term
Antibody structure consists of 4 proteins which are:
Definition
Pair of identical 2 heavy chains
2 light chains
Term
T cell receptor structure are made up of:
Definition
same size: alpha and beta
Term
What is an epitope?
Definition
Protein on the antigen that binds to antigen binding site
Term
Antibodies only bind to:
Definition
native structure
Term
T cells only bind to:
Definition
ONE THING (ONLY peptides that are tightly associated w/ other molecules aka - ACCESSORY MOLECULES)
Term
Accessory molecules:
Definition
Major Histocompatibility Complex MHC)
Human Leukocyte Antigen (HLA)
Term
Two different types of T cells that are needed to eliminate pathogens:
Definition
CD4
CD8
Term
Pathogens that live INSIDE cells get represented by:
Definition
HLA CLASS I
Term
HLA class I binds to?
Definition
Cd8
Term
Pathogens that live OUTSIDE the cell get represented by:
Definition
HLA CLASS II
Term
HLA CLASS II binds to:
Definition
Cd4
Term
CD8 binding to HLA class I induces what to the cell?
Definition
APOPTOSIS - gets rid of virus
Term
Does apoptosis occur in the cell when CD4 binds to HLA class II?
Definition
NO- need to alert the rest of the body
Term
A B cell receptor looks like which Class protein?
Definition

(Mnemonic::: B1T2)

class I (bc has heavy and light chains)

Term
A T cell receptor looks like which Class protein?
Definition

(Mnemonic::: B1T2)

CLASS II because has 2 similar size chains (alpha and beta)

Term
Extracellular and Intracellular Pathogens must be treated differently in the cell:
Where do extracellular pathogens end up in the cell?
Definition
VESICLE
Term
Extracellular and Intracellular Pathogens must be treated differently in the cell:
Where do intracellular pathogens end up in the cell?
Definition
ER
Term
Where do HLA class I and II get synthesize inside the cell?
Definition
ER (protein synthesis)
Term
What does TAP do in the ER?
Definition
Membrane bound protein that transports peptide fragments from cytosol into ER
Term
What is the purpose of changing the proteosome subunits and increasing the production of HLA class I?
Definition
Make virally infected cells better targets for CD8 T cell killing
Term
How to maximize peptide presentation?
Definition
MHC molecules are polygenic. MHC molecules are polymorphic. NOTE: for T cell, it's gene rearrangement
Term
The ability of HLA molecules to present repertoire of peptides:
Definition
polygeneism
Anchor residues
Term
Anchor resides:
Definition
The AA (of the antigen peptide) that the HLA molecule attach to
Supporting users have an ad free experience!